研究室の業績

2023年度

  1. De Novo Design of a Versatile Peptide-Based Coating to Impart Targeted Functionality at the Surface of Native Polystyrene.

    Yamada Y, Anderson CF, Schneider JP.

    ACS Appl Mater Interfaces, 15, 27560-27567. (2023)

     
  2. Chain-specificity of laminin α1-5 LG45 modules in the recognition of carbohydrate-linked receptors and intramolecular binding.

    Matsunuma M, Kan R, Yamada Y, Hamada K, Kanagawa M, Nomizu M, Kikkawa Y.

    Sci Rep, 13, 10430. (2023)

     
  3. Development of a concise and reliable method for quantifying the antibody loaded onto lipid nanoparticles modified with Herceptin.

    Yano Y, Tada R, Hamano N, Haruta K, Kobayashi T, Sato M, Kikkawa Y, Endo-Takahashi Y, Nomizu M, Negishi Y.

    J Immunol Methods, 521, 113554. (2023)

     
  4. Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity.

    Omura N, Taguchi A, Kuwahara T, Hamada K, Watanabe M, Nakakuki M, Konno S, Takayama K, Taniguchi A, Nomura T, Shuto S, Hayashi Y.

    ACS Med Chem Lett, 14, 1807-1814. (2023)

2022年度

  1. Influence of novel readthrough agents on myelin protein zero translation in the peripheral nervous system.
    Otani Y, Taguchi A, Hamada K, Hayashi Y, Yamaguchi Y, Baba H.
    Neuropharmacology, 211, 109059. (2022)
     
  2. RGDX1X2 motif regulates integrin αvβ5 binding for pluripotent stem cell adhesion.
    Yamada Y, Onda T, Hagiuda A, Kan R, Matsunuma M, Hamada K, Kikkawa Y, Nomizu M.
    FASEB J, 36, e22389. (2022)
     
  3. Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity.
    Zhang Y, Yan T, Wang T, Liu X, Hamada K, Sun D, Sun Y, Yang Y, Wang J, Takahashi S, Wang Q, Krausz KW, Jiang C, Xie C, Yang X, Gonzalez FJ. 
    Acta Pharm Sin B, 12, 2224-2238. (2022)
     
  4. Effect of amino acid substitution on cell adhesion properties of octa-arginine.
    Yamada Y, Onda T, Hamada K, Kikkawa Y, Nomizu M.
    Biol Pharm Bull, 45, 1537-1543. (2022)
     
  5. Laminin α5_CD239_Spectrin is a candidate association that compensates the linkage between the basement membrane and cytoskeleton in skeletal muscle fibers.
    Kikkawa Y, Matsunuma M, Kan R, Yamada Y, Hamada K, Nomizu M, Negishi Y, Nagamori S, Toda T, Tanaka M, Kanagawa M.
    Matrix Biol Plus, 15, 100118. (2022)
     
  6. A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects.
    Kaimori JY, Kikkawa Y, Motooka D, Namba-Hamano T, Takuwa A, Okazaki A, Kobayashi K, Tanigawa A, Kotani Y, Uno Y, Yoshimi K, Hattori K, Asahina Y, Kajimoto S, Doi Y, Oka T, Sakaguchi Y, Mashimo T, Sekiguchi K, Nakaya A, Nomizu M, Isaka Y.
    JCI Insight, 7, e158378. (2022)
  7. Structural Requirement of hA5G18 peptide (DDFVFYVGGYPS) from Laminin α5 Chain for Amyloid-like Fibril Formation and Cell Adhesion.
    Zhang G, Yamada Y, Kumai J, Hamada K, Kikkawa Y, Nomizu M.
    Molecules, 27, 6610. (2022)
     
  8. Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer.
    Velenosi TJ, Krausz KW, Hamada K, Dorsey TH, Ambs S, Takahashi S, Gonzalez FJ. 
    NPJ Precis Oncol, 6, 70. (2022)
     
  9. Development of an Antibody Delivery Method for Cancer Treatment by Combining Ultrasound with Therapeutic Antibody-Modified Nanobubbles Using Fc-Binding Polypeptide.
    Yano Y, Hamano N, Haruta K, Kobayashi T, Sato M, Kikkawa Y, Endo-Takahashi Y, Tada R, Suzuki R, Maruyama K, Nomizu M, Negishi Y.
    Pharmaceutics, 15, 130. (2022)
     
  10. Intestinal Peroxisome Proliferator-Activated Receptor α-Fatty Acid Binding Protein 1 Axis Modulates Nonalcoholic Steatohepatitis.
    Yan T, Luo Y, Yan N, Hamada K, Zhao N, Xia Y, Wang P, Zhao C, Qi D, Yang S, Sun L, Cai J, Wang Q, Jiang C, Gavrilova O, Krausz KW, Patel DP, Yu X, Wu X, Hao H, Liu W, Qu A, Gonzalez FJ.
    Hepatology, 77, 239-255. (2023)
     
  11. Structure-activity relationships of RGD-containing peptides in integrin αvβ5-mediated cell adhesion.
    Yamada Y, Onda T, Wada Y, Hamada K, Kikkawa Y, Nomizu M.
    ACS Omega, 8, 4687-4693. (2023)
     
  12. Development of a bispecific DNA aptamer-based lysosome targeting chimera for HER2 protein degradation.
    Hamada K, Hashimoto T, Iwashita R, Yamada Y, Kikkawa Y, Nomizu M.
    Cell Rep Phys Sci, 4, 101296. (2023)

2021年度

  1. Ternary complexes of pDNA, neuron-binding peptide, and PEGylated polyethyleneimine for brain delivery with nano-bubbles and ultrasound.
    Endo-Takahashi Y, Kurokawa R, Sato K, Takizawa N, Katagiri F, Hamano N, Suzuki R, Maruyama K, Nomizu M, Takagi N, Negishi Y.
    Pharmaceutics, 13, 1003. (2021)
     
  2. St. John's Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism.
    Yan T, Luo Y, Xia Y, Hamada K, Wang Q, Yan N, Krausz KW, Ward JM, Hao H, Wang P, Gonzalez FJ.
    FASEB J, 35, e21968. (2021)
     
  3. Withaferin A in the treatment of liver diseases: progress and pharmacokinetic insights.
    Xia Y, Yan M, Wang P, Hamada K, Yan N, Hao H, Gonzalez FJ, Yan T.
    Drug Metab Dispos, 50, 685-693. (2022)
     
  4. Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis.
    Hamada K, Wang P, Xia Y, Yan N, Takahashi S, Krausz KW, Hao H, Yan T, Gonzalez FJ.
    Food Chem Toxicol, 160, 112807. (2022)
     
  5. Octa-arginine and Octa-lysine Promote Cell Adhesion through Heparan Sulfate Proteoglycans and Integrins.
    Yamada Y, Onda T, Hamada K, Kikkawa Y, Nomizu M.
    Biol Pharm Bull, 45, 207-212. (2022)
     
  6. Fibulin-4 accelerates amyloid formation through binding with a keratin 5 peptide fragment.
    Katagiri F, Ueo D, Okubo-Gunge Y, Usui A, Kuwatsuka S, Mine Y, Hamada K, Fujiwara S, Sasaki T, Nomizu M, Utani A.
    JID Innovations, 2, 100114. (2022)

2020年度

  1. Evaluation of extracellular matrix mimetic laminin bioactive peptide and elastin-like polypeptide.

    Truong AT, Hamada K, Yamada Y, Guo H, Kikkawa Y, Okamoto CT, MacKay JA, Nomizu M.

    FASEB J, 34, 6729-6740. (2020)

     
  2. Development of three-dimensional cell culture scaffolds using laminin peptide-conjugated agarose microgels.

    Yamada Y, Yoshida C, Hamada K, Kikkawa Y, Nomizu M. 

    Biomacromolecules, 21, 3765-3771. (2020)

     
  3. Conformational dependence of integrin-binding peptides derived from homologous loop regions in the laminin α chains.

    Ishikawa M, Hamada K, Yamada Y, Kumai J, Katagiri F, Kikkawa Y, Nomizu M.

    J Pept Sci, e3284. (2020)

     
  4. Alpha-dystroglycan binding peptide A2G80-modified stealth liposomes as a muscle-targeting carrier for Duchenne muscular dystrophy.

    Sasaki E, Hayashi Y, Kimura Y, Sashida S, Hamano N, Nirasawa K, Hamada K, Katagiri F, Kikkawa Y, Sakai T, Yoshida A, Kawada M, Hirashima SI, Miura T, Endo-Takahashi Y, Nomizu M, Negishi Y.

    J Control Release, 329, 1037-1045. (2020)

     
  5. Development of A2G80 peptide-gene complex for targeted delivery to muscle cells.

    Nirasawa K, Hamada K, Naraki Y, Kikkawa Y, Sasaki E, Endo-Takahashi Y, Hamano N, Katagiri F, Nomizu M, Negishi Y.

    J Control Release, 329, 988-996. (2020)

     
  6. Dimerization of doxorubicin causes its precipitation.

    Yamada Y.

    ACS Omega, 5, 33235-33241. (2020)

     
  7. Effects of laminin-111 peptide coatings on rat neural stem/progenitor cell culture.

    Hayashi H, Horinokita I, Yamada Y, Hamada K, Takagi N, Nomizu M.

    Exp Cell Res, 400, 112440. (2020)

     
  8. Serum protein adsorption modulates the toxicity of highly positively charged hydrogel surfaces.

    Yamada Y, Fichman G, Schneider JP.

    ACS Appl Mater Interfaces, 13, 8006-8014. (2021)

     
  9. Laminin β2 variants associated with isolated nephropathy that impact matrix regulation.

    Kikkawa Y, Hashimoto T, Takizawa K, Urae S, Masuda H, Matsunuma M, Yamada Y, Hamada K, Nomizu M, Liapis H, Hisano M, Akioka Y, Miura K, Hattori M, Miner JH, Harita Y.

    JCI Insight, 6, e145908. (2021)

     
  10. Tissue substructure-specific deposition of the β3-containing laminin-332 in the biliary epithelium of human and mouse livers.

    Yamada M, Okada H, Kikkawa Y, Miyajima A, Itoh T.

    Biochem Biophys Res Commun, 524, 465-471. (2021)

2019年度

  1. Semiquantitative analysis of virtual histology derived from intravascular ultrasound images at vascular access stenosis.

    Sato T, Otsuka Y, Kikkawa Y, Iwasaki Y, Fukagawa M.

    J Vasc Access, 20, 55-59. (2019)

     
  2. Laminin-derived peptides: Applications in drug delivery systems for targeting. (Review)

    Negishi Y, Nomizu M.

    Pharmacol Ther, 202, 91-97. (2019)

     
  3. Development of antibody-modified nanobubbles using Fc-region-binding polypeptides for ultrasound imaging.

    Hamano N, Kamoshida S, Kikkawa Y, Yano Y, Kobayashi T, Endo-Takahashi Y, Suzuki R, Maruyama K, Ito Y, Nomizu M, Negishi Y.

    Pharmaceutics, 11, 283. (2019)

     
  4. Characterization of dystroglycan binding in adhesion of human induced pluripotent stem cells to laminin-511 E8 fragment.

    Sugawara Y, Hamada K, Yamada Y, Kumai J, Kanagawa M, Kobayashi K, Toda T, Negishi Y, Katagiri F, Hozumi K, Nomizu M, Kikkawa Y.

    Sci Rep, 9, 13037. (2019)

     
  5. Disrupted tubular parathyroid hormone/parathyroid hormone receptor signaling and damaged tubular cell viability possibly trigger postsurgical kidney injury in patients with advanced hyperparathyroidism.

    Sato T, Kikkawa Y, Yamamoto S, Tanaka Y, Kazama JJ, Tominaga Y, Ichimori T, Okada M, Hiramitsu T, Fukagawa M.

    Clin Kidney J, 12, 686-692. (2019)

     
  6. Identification of active sequences in human laminin α5 G domain.

    Kumai J, Yamada Y, Hamada K, Katagiri F, Hozumi K, Kikkawa Y, Nomizu M.

    J Pept Sci, 12, e3218. (2019)

     
  7. Design of a peptide-based electronegative hydrogel for the direct encapsulation, 3-D culturing, in vivo syringe-based delivery, and long-term tissue engraftment of cells.

    Yamada Y, Patel NL, Kalen JD, Schneider JP.

    ACS Appl Mater Interfaces, 11, 34688-34697. (2019)

     
  8. Electrostatically-driven guanidinium interaction domains that control hydrogel-mediated protein delivery in vivo.

    Miller SE, Yamada Y, Patel NL, Suárez E, Andrews C, Tau S, Luke BT, Cachau RE, Schneider JP.

    ACS Cent Sci, 5, 1750-1759. (2019)

     
  9. Ubr1p-Cup9p-Ptr2p pathway involves in the sensitivity to readthrough compounds negamycin derivatives in budding yeast.

    Hamada K, Naito A, Hamaguchi Y, Kanesaki Y, Kasahara K, Taguchi A, Omura N, Hayashi Y, Usui T.

    Biosci Biotechnol Biochem, 83, 1889-1892. (2019)

     
  10. New negamycin-based potent readthrough derivative effective against TGA-type nonsense mutations.

    Hamada K, Omura N, Taguchi A, Baradaran-Heravi A, Kotake M, Arai M, Takayama K, Taniguchi A, Roberge M, Hayashi Y.

    ACS Med Chem Lett, 10, 1450-1456. (2019)

     
  11. Fibulin-7 C-terminal fragment and its active synthetic peptide suppress choroidal and retinal neovascularization.

    Ikeuchi T, Kanan Y, Long D, de Vega S, Hozumi K, Nomizu M, Campochiaro PA, Yamada Y.

    Microvasc Res, 129, 103986. (2020)

2018年度

  1. Biological activities of laminin-111-derived peptide-chitosan matrices in a primary culture of rat cortical neurons.

    Hayashi H, Yamada M, Kumai J, Takagi N, Nomizu M.

    Arch Biochem Biophys, 648, 53-59, (2018)

     
  2. Internalization of CD239 highly expressed in breast cancer cells: a potential antigen for antibody-drug conjugates.

    Kikkawa Y, Enomoto-Okawa Y, Fujiyama A, Fukuhara T, Harashima N, Sugawara Y, Negishi Y, Katagiri F, Hozumi K, Nomizu M, Ito Y.

    Sci Rep, 8, 6612. (2018)

     
  3. Laminin-521 protein therapy for glomerular basement membrane and podocyte abnormalities in a model of Pierson syndrome.

    Lin MH, Miller JB, Kikkawa Y, Suleiman HY, Tryggvason K, Hodges BL, Miner JH.

    J Am Soc Nephrol, 29, 1426-1436. (2018)

     
  4. Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration.

    Miura Y, Matsui S, Miyata N, Harada K, Kikkawa Y, Ohmuraya M, Araki K, Tsurusaki S, Okochi H, Goda N, Miyajima A, Tanaka M.

    elife, 7, e36572. (2018)

     
  5. Development of a screening system for targeting carriers using peptide-modified liposomes and tissue sections.

    Negishi Y, Hamano N, Sato H, Katagiri F, Takatori K, Endo-Takahashi Y, Kikkawa Y, Nomizu M.

    Biol Pharm Bull, 41, 1107-1111. (2018)

     
  6. Cell adhesion activity of peptides conjugated to polysaccharides.

    Hozumi K, Nomizu M.

    Curr Protoc Cell Biol, 80, e53. (2018)

     
  7. Mixed peptide-conjugated chitosan matrices as multi-receptor targeted cell-adhesive scaffolds. (Review)

    Hozumi K, Nomizu M.

    Int J Mol Sci, 19, 2713. (2018)

     
  8. Macromolecule-network electrostatics controlling delivery of the biotherapeutic cell modulator TIMP-2.

    Yamada Y, Chowdhury A, Schneider JP, Stetler-Stevenson WG.

    Biomacromolecules, 19, 1285-1293. (2018)

     
  9. Identification of specific integrin cross-talk for dermal fibroblast cell adhesion using a mixed peptide-chitosan matrix.

    Hozumi K, Teranishi Y, Enomoto S, Katagiri F, Kikkawa Y, Nomizu M,

    J Biomater Appl, 33, 893-902. (2019)