研究室の業績

2022年度の研究室の業績

原著

Novel oleanane-type triterpene glycosides from the Saponaria officinalis L. seeds and apoptosis-inducing activity via mitochondria
Int J Mol Sci, 23, e2047 (2022)

Naoki Takahashi, Tomoki Iguchi, Minpei Kuroda, Masaki Mishima, Yoshihiro Mimaki
 
Chemical components from the leaves of Hedera rhombea and their cytotoxicity

Chem Pharm Bull, 70, 175-181 (2022)
Akihito Yokosuka, Tatsuya Shimomura, Shohei Yokogawa, Airi Oguro, Katsunori Miyake, and Yoshihiro Mimaki
 
Screening for aldose reductase inhibitory activity of 92 crude drugs, and isolation and identification of active ingredients from Clove
Jpn J Pharmacog, 76, 16-20 (2022)
Tomoki Iguchi, Minpei Kuroda, Yuki Itayama, Yoshihiro Mimaki

2021年度研究室の業績

原著

Digipregnosides A–C, three novel rearranged 11,12-secopregnane glycosides, and digipregnosides D and E, 12,20-epoxypregnane glycosides from the seeds of Digitalis purpurea
Tetrahedron Lett., 70, 153020 (2021)
Kazuhiro Takatori, Minpei Kuroda, Masaki Mishima, Yukiko Matsuo, Yoshihiro Mimaki
 
Steroidal glycosides from the aerial parts of Avena sativa L. and their cytotoxic activity
J Agric Food Chem, 76, 78-82 (2021)
Akihito Yokosuka, Keita Ishihara, Tsuyoshi Yamada, Tomoki Iguchi, Yoshihiro Mimaki
 
Structure and cytotoxicity of novel lignans and lignan glycosides from the aerial parts of Larrea tridentata
Molecules, 26, e6186 (2021)
Akihito Yokosuka, Tomoki Iguchi, Maki Jitsuno, Yoshihiro Mimaki
 
Chemical constituents of the whole plant of Verbena hastata and their inhibitory activity against the production of AGEs
Nat. Prod. Commun., 16, 1–5 (2021)
Akihito Yokosuka, Misaki Honda, Hitoshi Kondo, Yoshihiro Mimaki
 
Three novel furospirostanol glycosides and a steroidal alkaloid glycoside from the bulbs of Fritillaria camtschatcensis (L.) Ker Gawl., and their cytotoxicity
Nat. Prod. Res., Mar. 10, 1–7 (2021)
Tomoki Iguchi, Minpei Kuroda, Hiroshi Takayama, Yoshihiro Mimaki
 
Bufadienolides and ecdysteroids from the whole plants of Helleborus niger and their cytotoxicity
J. Nat. Med., 75, 393-402 (2021)
Akihito Yokosuka, Mina Inomata, Yuka Yoshizawa, Tomoki Iguchi, Yoshihiro Mimaki
 
Chemical Constituents of the Bulbs of Scilla peruviana and their pancreatic lipase inhibitory activity
Int. J. Mol. Sci., 22, 1262 (2021)
Yukiko Matsuo, Asuka Yamashiro, Kanae Ootomo, Mika Nakagawa, Hiroko Tsuchihashi, Niro Inaba, Yoshihiro Mimaki

2020年度研究室の業績

原著
 
Analysis of the ingredients in the decoctions and extracts of Kampo medicines
-The saccharides in Koi and Daikenchuto, and their influence on blood glucose levels-
Pharmacometrics, 99, 79-84 (2020)
Takashi Shii, Minpei Kuroda, Moe Yonekura, Yukiko Matsuo, Niro Inaba, Yoshihiro Mimaki
 
Chemical constituents and aldose reductase inhibitory activities of Betula alba bark and leaves
Nat. Prod. Res., Oct. 30, 1–5 (2020)
Tomoki Iguchi, Minpei Kuroda, Nanami Akiyama, Mariko Hashimoto, Yoshihiro Mimaki
 
A total of eight novel steroidal glycosides based on spirostan, furostan, pseudofurostan, and cholestane from the leaves of Cestrum newellii
Molecules, 25, 4462 (2020)
Tomoki Iguchi, Naoki Takahashi, Yoshihiro Mimaki
 
Identification of flavone C-glycosides from Glycyrrhiza uralensis seeds and their effects on AMPK activation
Jpn. J. Pharmacog., 74, 108-109 (2020)
Yukiko Matsuo, Tomoki Iguchi, Minpei Kuroda, Mizue Ishiguro, Takuro Nara, Kazuhiro Takatori, Yoshihiro Mimaki
 
Steroidal glycosides from the bulbs of Lilium speciosum
Phytochem. Lett., 37, 21-28 (2020)
Tomoki Iguchi, Akihito Yokosuka, Minpei Kuroda, Mayuko Takeya, Mizuki Hagiya, Yoshihiro Mimaki
 
Bufadienolide glycosides and bufadienolides from the whole plants of Helleborus lividus, and their cytotoxic activity
Phytochemistry, 176, 112415 (2020)
Tomoki Iguchi, Akihito Yokosuka, Naoya Tamura, Shingo Takano, Yoshihiro Mimaki
 
Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity
Phytochemistry, 173, 112301 (2020)
Yukiko Matsuo, Emi Yamaguchi, Ryo Hakamata, Kanae Ootomo, Kazuhiro Takatori, Haruhiko Fukaya, Yoshihiro Mimaki
 
Novel steroidal glycosides from the whole plants of Helleborus foetidus
Chem. Pharm. Bull., 68, 273-287 (2020)
Tomoki Iguchi, Yuka Uchida, Shingo Takano, Akihito Yokosuka, Yoshihiro Mimaki
 
Bufadienolides from the whole plants of Helleborus foetidus and their cytotoxicity
Phytochemistry, 172, 112277 (2020)
Tomoki Iguchi, Akihito Yokosuka, Riko Kawahata, Madoka Andou, Yoshihiro Mimaki
 
An analysis of the ingredients in decoctions and extracts of Kampo medicines: amounts of baicalin and baicalein in Kampo medicines containing Scutellariae Radix
Jpn. J. Geriat., 57, 72-80 (2020)
Takashi Shii, Minpei Kuroda, Noriko Shamoto, Yoshihiro Mimaki
 
Chemical constituents of the terrestrial stems of Ephedra sinica and their PPAR-γ ligand-binding activity
Planta Med. Int. Open, 7, 1-5 (2020)
Yukiko Matsuo, Mayu Sasaki, Haruhiko Fukaya, Katsunori Miyake, Riko Takeuchi, Hidetoshi Kumata, Yoshihiro Mimaki
 
A new and 23 known cardenolide glycosides from Thevetia neriifolia seeds and their cytotoxic activities against human oral carcinoma cell lines
Nat. Prod. Res., Jan 22, 1-6 (2020)
Satoru Tatsuno, Tomoki Iguchi, Minpei Kuroda, Mai Ishihara, Hiroshi Sakagami, Yoshihiro Mimaki
 
Chemical constituents in the whole-plant extract of Agrimonia eupatoria and their adose reductase inhibitory activities
Jpn. J. Phrmacog., 74, 60-61 (2020)
Tomoki Iguchi, Minpei Kuroda, Ami Izumisawa, Marina Ishii, Yoshihiro Mimaki
 
Chemical constituents of Trifolium pratense seeds
Jpn. J. Phrmacog., 74, 58-59 (2020)
Tomoki Iguchi, Minpei Kuroda, Ami Izumisawa, Marina Ishii, Yoshihiro Mimaki

2019年度研究室の業績

原著

Steroidal constituents isolated from the seeds of Withania somnifera
Tomoki Iguchi, Minpei Kuroda, Mai Ishihara, Hiroshi Sakagami, Yoshihiro Mimaki
Nat. Prod. Res., Sep 20, 1-6 (2019)
 
Chemical constituents from the aerial parts of Achillea millefolium and their aldose reductase inhibitory activity
Jpn. J. Pharmacog., 73, 91-92 (2019)
Tomoki Iguchi, Minpei Kuroda, Kei Narita, Yoshihiro Mimaki
 
Total synthesis and determination of the absolute configuration of paralemnolin C and biological studies of eremophilane derivatives
Hideki Abe, Mitsuru Fujimaki, Ena Goto, Akihito Yokosuka, Yoshihiro Mimaki, Toyoharu Kobayashi, Hisanaka Ito
Tetrahedron Lett., 60, 1604-1606 (2019)
 
Triterpene Glycosides from the Seeds of Dolichos lablab
Akihito Yokosuka, Hiroki Takayama, Yoshihiro Mimaki
Chem. Pharm. Bull., 67, 604-608 (2019)
 
Cycloartane and oleanane glycosides from the tubers of Eranthis cilicica
Molecules, 24, 69 (2019)
Kazuki Watanabe, Yoshihiro Mimaki, Haruhiko Fukaya, Yukiko Matsuo
 
Cholestane glycosides from Ornithogalum saundersiae bulbs and the induction of apoptosis in HL-60 cells by OSW-1 through a mitochondrial-independent signaling pathway
Tomoki Iguchi, Minpei Kuroda, Rei Naito, Tomoyuki Watanabe, Yukiko Matsuo, Akihito Yokosuka, Yoshihiro Mimaki
J. Nat. Med., 73, 131-145 (2019)
 
Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity
Satoru Tatsuno, Akihito Yokosuka, Fusako Hatsuma, Yuto Mashiko, Yoshihiro Mimaki
J. Nat. Med., 73, 93-103 (2019)

2018年度研究室の業績

原著

Cycloartane and oleanane glycosides from the tubers of Eranthis cilicica
Molecules, 24, E69 (2018)
Kazuki Watanabe, Yoshihiro Mimaki, Haruhiko Fukaya, Yukiko Matsuo
 
Daisaikoto Inhibits Pancreatic Lipase Activity and Decreases Serum Triglyceride Levels in Mice
Yukiko Matsuo, Kenya Matsumoto, Niro Inaba, Yoshihiro Mimaki
Biol. Pharm. Bull., 41, 1485-1488 (2018)
 
Aestivalosides A-​L, twelve pregnane glycoides from the seeds of Adonis aestivalis
Minpei Kuroda, Satoshi Kubo, Daichi Masatani, Yukiko Matsuo, Hiroshi Sakagami, Yoshihiro Mimaki
Phytochemistry, 150, 75-84 (2018)
 
Total synthesis of catunaregin and preliminary evaluation of its antitumor Activity
Hideki Abe, Takuma Hikichi, Kosuke Emori, Akihito Yokosuka, Yoshihiro Mimaki, Toyoharu Kobayashi, Hisanaka Ito
Eur. J. Org. Chem., 1655-1664 (2018)
 
Nobiletin reduces intra- and extracellular Aβ in iPS cell-derived Alzheimer's disease model neurons
Junko Kimura, Kosuke Shimizu, Koji Kajima, Akihito Yokosuka, Yoshihiro Mimaki, Naoto Oku, Yasushi Ohizumi
Biol. Pharm. Bull., 41, 451-457 (2018)
 
Discrimination of Schisandrae Chinensis Fructus and Schisandrae Sphenantherae Fructus based on fingerprint profiles of hydrophilic components by high-performance liquid chromatography with ultraviolet detection
Ryusei Oshima, Akira Kotani, Minpei Kuroda, Kazuhiro Yamamoto, Yoshihiro Mimaki, Hideki Hakamata
J. Nat. Med., 72, 399-408 (2018)
 
Cytotoxic bufadienolides from the whole plants of Helleborus foetidus
Akihito Yokosuka, Tomoki Iguchi, Riko Kawahata, Yoshihiro Mimaki
Phytochemistry Lett. 23, 94-99 (2018)
 
AU-1 from Agavaceae plants downregulates the expression of glycolytic enzyme phosphoglycerate mutase
Tomofumi Fujino, Akihito Yokosuka, Harutaka Ichikawa, Toshiyuki Oshima, Yoshihiro Mimaki, Makio Hayakawa
J. Nat. Med. 72, 342-346 (2018)

2017年度研究室の業績

原著

Steroidal glycosides from Convallaria majalis whole plants and their cytotoxic activity
Yukiko Matsuo, Daisuke Shinoda, Aina Nakamaru, Kuni Kamohara, Hiroshi Sakagami, Yoshihiro Mimaki
Int. J. Mol .Sci., 18, e2358 (2017)
 
Structural characterization of cholestane rhamnosides from Ornithogalum saundersiae bulbs and their cytotoxic activity against cultured tumor cells
Molecules, 22, e1243 (2017)
Tomoki Iguchi, Minpei Kuroda, Rei Naito, Tomoyuki Watanabe, Yukiko Matsuo, Akihito Yokosuka, Yoshihiro Mimaki
 
Oral administration of sinensetin, but not nobiletin alone prevents MK801-induced impairment of memory formation in mice, like nobiletin-rich chinpi, a Kampo medicine
Traditional & Kampo Medicine, 4, 116-120 (2017)
Wen Sun, Ichiro Kawahata, Huinan Xu, Masaaki Yoshida, Hidehiro Ando, Akihito Yokosuka, Yoshihiro Mimaki, Tohru Yamakuni
 
Chemical constituents of the bulbs of Haemanthus multiflorus
Phytochemistry Lett., 21, 6-10 (2017)
Akihito Yokosuka, Natsumi Suzuki, Yoshihiro Mimaki
 
Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4'-demethylnobiletin prevents MK801-induced memory impairment
J. Nat. Med., 71, 617-631 (2017)
Ichiro Kawahata, Tatsuya Suzuki, Evelyn Gutierrez Rico, Shuichi Kusano, Hiroshi Tamura, Yoshihiro Mimaki, Tohru Yamakuni
 
AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in a miR-34-dependent manner
J. Nat. Med.,71, 36-43 (2017)
Tomofumi Fujino, Akihito Yokosuka, Hideaki Higurashi, Rina Yokokawa, Ryo Sakurai, Wataru Harashima, Yuichi Miki, Yasuyuki Fujiwara, Yoshihiro Mimaki, Makio Hayakawa
 
Chemical compounds from the leaves of Verbascum thapsusand their xanthine oxidase inhibitory activity
Jpn. J. Pharmacog., 71, 49-50 (2017)
Minpei Kuroda, Katsura Iwabuchi, Saori Usui, Nanami Akiyama, Yoshihiro Mimaki

2016年度研究室の業績

原著

A new neolignan glycoside from Vetiveria zizanioides root
Nat. Prod. Commun.11, 983-985 (2016)
Yukiko Matsuo, Chika Ohba, Saori Maeda, Haruhiko Fukaya, Yoshihiro Mimaki
 
Chemical constituents of the leaves of Tussilago farfara and their aldose reductase inhibitory activity
Nat. Prod. Commun., 11, 1661-1664 (2016)
Minpei Kuroda, Takumi Ohshima, Chihiro Kan, Yoshihiro Mimaki
 
Vetiverianines A, B, and C: sesquiterpenoids from Vetiveria zizanioides roots
J. Nat. Prod. 79, 2175-2180 (2016)
Yukiko Matsuo, Saori Maeda, Chika Ohba, Haruhiko Fukaya, Yoshihiro Mimaki
 
Stryphnosides G-P, 10 new triterpene glycosides from the pericarps of Stryphnodendron fissuratum
Carbohydr. Res.
434, 18-26 (2016)
Akihito Yokosuka, Genki Okabe, Satoru Tatsuno, Yoshihiro Mimaki
 
Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC-12 cells
Can. J. Physiol. Pharmacol.94, 728-733 (2016)
Jiro Takito, Junko Kimura, Koji Kajima, Nobuyuki Uozumi, Makoto Watanabe, Akihito Yokosuka, Yoshihiro Mimaki, Masanori Nakamura, Yasushi Ohizumi

2015年度研究室の業績

原著

Novel Steroidal Glycosides from the Bulbs of Lilium pumilum
Molecules, 
20, 16255-162655 (2015)
Yukiko Matsuo, Reina Takaku, Yoshihiro Mimaki
 
Chemical Constituents of the Underground Parts of Iris florentina and Their Cytotoxic Activity
Nat. Prod. Commun.10, 955–958 (2015)
Akihito Yokosuka, Yoshikazu Koyama, Yoshihiro Mimaki
 
Amurensiosides L-P, Five New Cardenolide Glycosides fromthe Roots of Adonis amurensis
Nat. Prod. Commun.
10, 27–32 (2015)
Satoshi Kubo, Minpei Kuroda, Akihito Yokosuka, Hiroshi Sakagami, Yoshihiro Mimaki
 
Karataviosides G-K, Five New Bisdesmosidic Steroidal Glycosides from the Bulbs of Allium karataviense 
Steroids
93, 96–104 (2015)
Minpei Kuroda, Kazutomo Ori, Hiroshi Takayama, Hiroshi Sakagami, Yoshihiro Mimaki
 
Cardenolide Glycosides from the Seeds of Digitalis purpurea Exhibit Carcinoma-​specific Cytotoxicity toward Renal Adenocarcinoma and Hepatocellular Carcinoma Cells
Biosci. Biotechnol. Biochem.79, 177–184 (2015)
Tomofumi Fujino, Minpei Kuroda, Yukiko Matsuo, Satoshi Kubo, Chikako Tamura, Nami Sakamoto, Yoshihiro Mimaki, Makio Hayakawa
 
Nobiletin, a Citrus flavonoid, Improves Cognitive Impairment and Reduces Soluble Aβ Levels in a Triple Transgenic Mouse Model of Alzheimer’s Disease (3XTg-AD)
Behav. Brain Res. 289, 69–77 (2015)
Akira Nakajima, Yuki Aoyama, Eun-Joo Shin, Yunsung Nam, Hyoung-Chun Kim, Taku Nagai, Akihito Yokosuka, Yoshihiro Mimaki, Tsuyoshi Yokoi, Yasushi Ohizumi, Kiyofumi Yamada
 
Upregulatory Effects of Nobiletin, a Citrus Flavonoid with Anti-dementia Activity, on the Gene Expression of mAChR, ChAT, and CBP 
Planta Med. Lett. 2, e12-e14 (2015)
Junko Kimura, Kosuke Shimizu, Jiro Takito, Kiyomitsu Nemoto, Masakuni Degawa, Akihito Yokosuka, Yoshihiro Mimaki, Naoto Oku, Yasushi Ohizumi

2014年度研究室の業績

原著

A Rare Type of Sesquiterpene and β-Santalol Derivatives from Santalum albumand Their Cytotoxic Activities
Chem. Pharm. Bull.62, 1192–1199 (2014)
Yukiko Matsuo, Hiroshi Sakagami, Yoshihiro Mimaki
 
Two New Homoisoflavonoids from the Bulbs of Bessera elegans
Nat. Prod. Commun.9, 725–1727 (2014)
Yukiko Matsuo, Risa Kurihara, Nana Akagi, Yoshihiro Mimaki
 
Steroidal Glycosides from the Underground Parts of Dracaena thalioides and Their Cytotoxic Activity
Phytochemistry107, 102-110 (2014)
Liying Tang, Zhuju Wang, Hongwei Wu, Akihito Yokosuka, Yoshihiro Mimaki
 
Steroidal Glycosides from the Underground Parts of Yucca glauca and Their Cytotoxic Activities
Phytochemistry101, 109-115 (2014)
Akihito Yokosuka, Tomoka Suzuki, Satoru Tatsuno, Yoshihiro Mimaki
 
New Acylated Triterpene Glycosides from the Roots of Polygala tenuifolia
Nat. Prod. Commun.9, 379-382 (2014)
Minpei Kuroda, Takaaki Shizume, Yoshihiro Mimaki
 
Triterpene Glycosides from the Stems and Leaves of Lonicera japonica
Chem. Pharm. Bull.62, 92–96 (2014)
Minpei Kuroda, Takaaki Shizume, Yoshihiro Mimaki
 
Estimation of Endoplasmic Reticulum Stress-inducing Ability of Nobiletin, a Citrus Polymethoxyflavonoid, in SK-N-SH Human Neuroblastoma Cells
Fund. Toxicol. Sci., 1, 169-172 (2014)
Ayaka Ikeda, Shingo Miyata, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degawa, Kiyomitsu Nemoto
 
Quantitative Analysis of F-Actin Redistribution in Astrocytoma Cells Treated with Candidate Pharmaceuticals
Cytometry Part A85, 512-521 (2014)
Stephen Lockett, Chrissie Verma, Alla Brafman, Prabhakar Gudla, Kaustav Nandy, Yoshihiro Mimaki, Philip L. Fuchs, Joseph Jaja, Karlyne M. Reilly, John Beutler, Thomas J. Turbyville
 
Nobiletin, a Flavone from Citrus depressa, Induces Gene Expression and Increases the Protein Level and Activity of Neprilysin in SK-N-SH CellsCan. J. Physiol. Pharmacol.92, 351-355 (2014)
Hironori Fujiwara, Junko Kimura, Masahiro Sakamoto, Akihito Yokosuka, Yoshihiro Mimaki, Kiyoshi Murata, Kikuji Yamaguchi, Yasushi Ohizumi
 
Upregulation of N-Methyl-D-Aspartate Receptor Subunits and c-Fos Expressing Genes in PC12D Cells by Nobiletin
Biol. Pharm. Bull.37, 1555-1558 (2014)
Junko Kimura, Kiyomitsu Nemoto, Masakuni Degawa, Akihito Yokosuka, Yoshihiro Mimaki, Kosuke Shimizu, Naoto Oku, Yasushi Ohizumi

2013年度研究室の業績

原著

Steroidal Glycosides from the Bulbs of Bessera elegans and Their Cytotoxic Activities
Phytochemistry96, 244–256 (2013)
Yukiko Matsuo, Nana Akagi, Chisato Hashimoto, Fumito Tachikawa, Yoshihiro Mimaki
 
Steroidal Glycosides from the Bulbs of Fritillaria meleagris and Their Cytotoxic Activities
Steroids78, 670–682 (2013)
Yukiko Matsuo, Daisuke Shinoda, Aina Nakamaru, Yoshihiro Mimaki
 
New Cholestane Glycosides and Sterols from the Underground Parts of Chamaelirium luteum and Their Cytotoxic Activity
J. Nat. Med.67, 590-598 (2013)
Akihito Yokosuka, Kenichi Takagi, Yoshihiro Mimaki
 
New Cardenolide Glycosides from the Seeds of Digitalis purpurea and Their Cytotoxic Activity
Biosci. Biotechnol. Biochem.77, 1186–1192 (2013)
Minpei Kuroda, Satoshi Kubo, Yukiko Matsuo, Tomomi Atou, Junichi Satoh, Tomofumi Fujino, Makio Hayakawa, Yoshihiro Mimaki
 
Chemical Constituents of the Leaves of Dracaena thalioides
Nat. Prod. Commun.8, 315-318 (2013)
Akihito Yokosuka, Atsushi Sekiguchi, and Yoshihiro Mimaki
 
Glaziovianin A, a Novel Microtubule Dynamics Inhibitor, Prevents Endosome Maturation
ACS Chem. Biol.8, 884-889 (2013)
Takumi Chinen, Sayaka Kazami, Yoko Nagumo, Ichiro Hayakawa, Akiyuki Ikedo, Masatoshi Takagi, Akihito Yokosuka, Naoko Imamoto, Yoshihiro Mimaki, Hideo Kigoshi, Hiroyuki Osada, Takeo Usui
 
Nobiletin, a Citrus Flavonoid, Ameliorates Cognitive Impairment, Oxidative Burden, and Hyperphosphorylation of Tau in Senescence-accelerated Mouse
Behav. Brain Res.250, 351-360 (2013)
Akira Nakajima, Yuki Aoyama, Thuy-Ty Lan Nguyen, Eun-Joo Shin, Hyoung-Chun Kim, Shinnosuke Yamada, Tsuyoshi Nakai, Taku Nagai, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Kiyofumi Yamada
 
Potent Activity of Nobiletin-rich Citrus reticulata Peel Extract to Facilitate cAMP/PKA/ERK/CREB Signaling Associated with Learning and Memory in Cultured Hippocampal Neurons: Identification of the Substances Responsible for the Pharmacological Action
J. Neural Transm.120, 1397-1409 (2013)
Ichiro Kawahata, Masaaki Yoshida, Wen Sun, Akira Nakajima, Yanxin Lai, Naoya Osaka, Kentaro Matsuzaki, Akihito Yokosuka, Yoshihiro Mimaki, Akira Naganuma, Yoshihisa Tomioka, Tohru Yamakuni
 
Suppressive Effect of Nobiletin, a Citrus Polymethoxyflavonoid that Downregulates Thioredoxin-interacting Protein Expression, on Tunicamycin-induced Apoptosis in SK-N-SH Human Neuroblastoma Cells
Neurosci. Lett.549, 135-139 (2013)
Ayaka Ikeda, Kiyomitsu Nemoto, Chiaki Yoshida, Shingo Miyata, Junki Mori, Saori Soejima, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degawa
 
6-Demethoxynobiletin, a Nobiletin-analog Citrus Flavonoid, Enhances Extracellular Signal-regulated Kinase Phosphorylation in PC12D Cells
Biol. Pharm. Bull.36, 1646-1649 (2013)
Junko Kimura, Kiyomitsu Nemoto, Akihito Yokosuka, Yoshihiro Mimaki, Masakuni Degawa, Yasushi Ohizumi
 
Nobiletin Induces Inhibitions of Ras Activity and Mitogen-activated Protein Kinase Kinase/Extracellular Signal-regulated Kinase Signaling to Suppress Cell Proliferation in C6 Rat Glioma Cells
Biol. Pharm. Bull.36, 540-547 (2013)
Koichi Aoki, Akihito Yokosuka, Yoshihiro Mimaki, Kohji Fukunaga, Tohru Yamakuni
 
Characteristics of Nobiletin-mediated Alteration of Gene Expression in Cultured Cell Lines
Biochem. Biophys. Res. Commun.431, 530-534 (2013)
Kiyomitsu Nemoto, Ayaka Ikeda, Chiaki Yoshida, Junko Kimura, Junki Mori, Hironori Fujiwara, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degawa

2012年度研究室の業績

原著

α-Santalol Derivatives from Santalum album and Their Cytotoxic Activities
Phytochemistry77, 304–311 (2012)
Yukiko Matsuo, Yoshihiro Mimaki
 
Triterpene Tetraglycosides from the Flowers of Verbascum thapsus
Jpn. J. Pharmacog., 66, 91–92 (2012)
Minpei Kuroda, Katsura Iwabuchi, Yoshihiro Mimaki
 
Chemical Constituents of the Aerial Parts of Scutellaria lateriflora and Their α-Glucosidase Inhibitory Activities
Nat. Prod. Commun.7, 471–474 (2012)
Minpei Kuroda, Katsura Iwabuchi, Yoshihiro Mimaki 
 
New Cardenolides from the Seeds of Adonis aestivalis
Chem. Pharm. Bull.60, 1275–1282 (2012)
Satoshi Kubo, Minpei Kuroda, Yukiko Matsuo, Daichi Masatani, Hiroshi Sakagami, Yoshihiro Mimaki
 
New Cholestane Glycosides from the Leaves of Cordyline terminalis
Chem. Pharm. Bull.60, 275-279 (2012)
Akihito Yokosuka, Takeyuki Suzuki, Yoshihiro Mimaki
 
Hypoglycemic Effects of Clove (Syzygium aromaticum Flower Buds) on Genetically Diabetic KK-Ay Mice and Identification of the Active Ingredients
J. Nat. Med.66, 394-399 (2012)
Minpei Kuroda, Yoshihiro Mimaki, Takayuki Ohtomo, Junji Yamada, Tozo Nishiyama, Tatsumasa Mae, Hideyuki Kishida, Teruo Kawada
 
Oral Administration of Cimicifuga rasemosa Extract Attenuates Immobilization Stress-Induced Reactions
Nat. Prod. Commun.7, 15-18 (2012)
Isao Nadaoka, Kazuki Watanabe, Masaaki Yasue, Manabu Sami, Yasushi Kitagawa, Yoshihiro Mimaki

2011年度研究室の業績

原著

Seven New Triterpene Glycosides from the Pericarps of Stryphnodendron fissuratum
Phytochem. Lett., 4, 259-266 (2011)
Akihito Yokosuka, Sachiko Kawakami, Mitsue Haraguchi, Yoshihiro Mimaki
 
Larrealignans A and B, Novel Lignan Glycosides from the Aerial Parts of Larrea tridentata
Chem. Pharm. Bull.59, 1467-1470 (2011)
Akihito Yokosuka, Yukiko Matsuo, Maki Jitsuno, Kohei Adachi, Yoshihiro Mimaki
 
Phenolic Glycosides from Rhodohypoxis baurii
J. Nat. Med.65, 224-228(2011)
Yukiko Matsuo, Fumito Tachikawa, Yoshihiro Mimaki
 
Chemical Constituents of the Stems and Twigs of Lindera umbellata
J. Nat. Med., 65, 198-201(2011)
Minpei Kuroda, Koichiro Sakurai, Yoshihiro Mimaki 
 
Chemical Constituents of Lycoris albiflora and Their Cytotoxic Activities 
Nat. Prod. Commun.6, 187-192(2011)
Maki Jitsuno, Akihito Yokosuka, Ken Hashimoto, Osamu Amano, Hiroshi Sakagami, Yoshihiro Mimaki
 
Chemical Components from the Rhizomes of Petasites japonicus and Their Cytotoxic Activity
Jpn. J. Pharmacog.64, 106-107(2011)
Akihito Yokosuka, Tomoe Sano, Yoshihiro Mimaki
 
Natural Products Reveal Cancer Cell Dependence on Oxysterol-binding Proteins
Nature Chem. Biol.7, 639-647 (2011)
Anthony W. G. Burgett, Thomas B. Poulsen, Kittikhun Wangkanont, D. Ryan Anderson, Chikako Kikuchi, Kousei Shimada, Shuichi Okubo, Kevin C. Fortner, Yoshihiro Mimaki, Minpei Kuroda, Jason P. Murphy, David J. Schwalb, Eugene C. Petrella, Ivan Cornella-Taracido, Markus Schirle, John A. Tallarico, Matthew D. Shair
 
High-performance Liquid Chromatography with Photodiodearray Detection for Determination of Nobiletin Content in the Brain and Serum of Mice Administrated the Natural Compound
Anal. Bioanal. Chem., 23, 3635-3641 (2011)
Daisuke Saigusa, Masatoshi Shibuya, Daisuke Jinno, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Akihito Yokosuka, Yoshihiro Mimaki, Akira Naganuma, Yasushi Ohizumi, Yoshihisa Tomioka, Tohru Yamakuni
 
Honeybee Royal Jelly and Nobiletin Stimulate CRE-Mediated Transcription in ERK-Independent and -Dependent Fashions, Respectively, in PC12D Cells
J. Pharmacol. Sci.116, 384-387 (2011)
Hironori Fujiwara, Ako Kogure, Masahiro Sakamoto, Tohru Yamakuni,  Yoshihiro Mimaki, Kiyoshi Murata, Nobuyuki Hitomi, Kikuji Yamaguchi, Yasushi Ohizumi
 
Inhibitory Effects of Citrus Polymethoxyflavones, Nobiletin and its Analogues, on Acetylcholinesterase Activity
Pharmacometrics81, 23-26 (2011)
Junko Kimura, Kiyomitsu Nemoto, Satomi Onoue, Tohru Yamakuni, Akihito Yokosuka, Yoshihiro Mimaki, Shizuo Yamada, Masakuni Degawa, Yasushi Ohizumi

2010年度研究室の業績

原著

Triterpene Glycosides from Curculigo orchioides and Their Cytotoxic Activity
J. Nat. Prod.73, 1102-1106(2010)
Akihito Yokosuka, Koji Sato, Takao Yamori, Yoshihiro Mimaki
 
Triterpene Glycosides from the Aerial Parts of Larrea tridentata
Phytochemistry71, 2157-2167(2010)
Maki Jitsuno, Yoshihiro Mimaki
 
Cycloartane Glycosides from the Rhizomes of Curculigo orchioides
Phytochemistry71, 2174-2181(2010)
Akihito Yokosuka, Koji Sato, Yoshihiro Mimaki
 
Lignans from Santalum album and Their Cytotoxic Activities
Chem. Pharm. Bull.58, 587-590(2010)
Yukiko Matsuo, Yoshihiro Mimaki
 
Furostanol Glycosides from the Rhizomes of Helleborus orientalis
J. Nat. Med.64, 452-459(2010)
Yoshihiro Mimaki, Yukiko Matsuo, Kazuki Watanabe, Hiroshi Sakagami
 
Chemical Constituents of the Stems and Twigs of Lindera umbellata
J. Nat. Med.65, 198-201(2010)
Minpei Kuroda, Koichiro Sakurai, and Yoshihiro Mimaki

学会発表記録

国際学会

工事中

国内学会

第122 回 日本薬理学会関東部会

2010 年6 月 於 静岡
木村 純子,根本 清光,山國  徹,尾上 誠良,山田 静雄,三巻 祥浩,指田  豊,出川 雅邦,大泉  康
  柑橘類果皮に含まれる抗認知症成分nobiletin およびその類似ポリメトキシフラボンの細胞内シグナル伝達および遺伝子発現に対する作用

日本生薬学会 第57 回年会・第 5 回 日中韓生薬合同シンポジウム

2010 年9 月 於 徳島
三巻 祥浩
  Chemical Studies of Plants for the Purpose of Searching for Leads on New Medicines
 
黒田 明平,鎭目 崇彰,三巻 祥浩
  漢方生薬の化学成分(10) 金銀花のトリテルペン配糖体について
 
櫻井幸市朗,黒田 明平,三巻 祥浩
  Zanthoxylum bungeanum 果皮の化学成分に関する研究
 
鈴木 健之,横須賀章人,三巻 祥浩
  リュウゼツラン科植物の化学成分(18) Cordyline terminalis の新規スピロスタン配糖体について
 
坂本かおり,清水 崇之,高橋 知也,横須賀章人,三巻 祥浩
  新疆雪蓮花のメラニン生成抑制成分について
 
松尾侑希子,三巻 祥浩
  ビャクダン(Santalum album)の細胞増殖抑制活性成分について(5)
 
篠田 大輔,松尾侑希子,三巻 祥浩
  ユリ科植物の化学成分(70) Fritillaria meleagris の成分について
 
實野 真季,三巻 祥浩
  伝承生薬の化学成分(15) Larrea tridentata の化学成分について(3)

有機合成化学協会ならびに関東支部 若手研究者のためのセミナー

2010 年9 月 於 千葉
横須賀章人,三巻 祥浩
  高等植物を由来とする新規生物活性物質の探索研究

第54 回 日本薬学会関東支部大会

2010 年10 月 於 東京
黒田 明平,岩淵かつら,三巻 祥浩 
  天然からの高尿酸血症に対する予防・改善素材の探索
 
櫻井幸市朗,黒田 明平,三巻 祥浩 
  生薬・黒文字および花椒の成分に関する研究
 
横須賀章人,佐野 智恵,三巻 祥浩
  キク科植物Petasites japonicus の化学成分について
 
鈴木 健之,横須賀章人,三巻 祥浩
  リュウゼツラン科植物の化学成分(19) Cordyline terminalis の化学成分
 
松尾侑希子,立川 史士,三巻 祥浩
  アッツザクラ(Rhodohypoxis baurii)から単離されたフェノール性配糖体について_
 
篠田 大輔,松尾侑希子,三巻 祥浩
  ユリ科Fritillaria meleagris の化学成分に関する研究

第18 回 天然薬物の開発と応用シンポジウム

2010 年11 月 於 東京
實野 真季,横須賀章人,三巻 祥浩,橋本  研,天野  修,坂上  宏
  ヒガンバナ科植物Habranthus brachyandrus およびLycoris albiflora の化学成分と細胞毒性に関する研究(6)

日本薬学会 第131 年会

2011 年3 月 於 静岡
黒田 明平,阿藤 友美,久保  聡,松尾侑希子,三巻 祥浩
  Digitalis purpurea 種子の化学成分について(1)
 
櫻井幸市朗,武井 浩昭,黒田 明平,三巻 祥浩
  Hedysarum polybotrys の化学成分に関する研究
 
横須賀章人,川上紗智子,原口 光枝,三巻 祥浩
  伝承生薬の化学成分(16) Stryphnodendron fissuratum の新規トリテルペン配糖体成分について
 
鈴木 健之,横須賀章人,三巻 祥浩
  リュウゼツラン科植物の化学成分(20) Cordyline terminalis の新規ステロイド配糖体について
 
松尾侑希子,赤城 那奈,立川 史士,三巻 祥浩
  ユリ科植物の化学成分(71) Bessera elegans の成分について
 
篠田 大輔,中丸 愛菜,松尾侑希子,三巻 祥浩
  ユリ科植物の化学成分(72) Fritillaria meleagris の成分について(2)
 
實野 真季,横須賀章人,三巻 祥浩,橋本  研,天野  修,坂上  宏
  ヒガンバナ科植物Habranthus brachyandrus およびLycoris albiflora の化学成分と細胞毒性に関する研究(7)
 
三枝 大輔,中島  晶,鐵  尚美,澁谷 正俊,山越 博幸,岩渕 好治,横須賀章人,指田  豊,三巻 祥浩,永沼  章,大泉  康,富岡 佳久,山國  徹
  HPLC/PDA 法を用いた体内動態解析による抗アルツハイマー病天然薬物ノビレチンの脳内移行の証明