1. 本間丈士, 亀山俊, 前田正輝, 堀口雅巳, 平野俊彦, 杉山健太郎 病院薬剤師と薬局薬剤師を対象とした関節リウマチ治療に関する意識調査 応用薬理 101(1/2) 7-14 2021
Kanazawa H, Obara H, Yoshikawa R, Meng L, Hirano T, Okada Y, Nishikawa Y, Matsuno N. Impact of machine perfusion on sinusoid microcirculation of liver graft donated after cardiac death. J Surg Res 254:410-419; 2020
Endo M, Hirano R, Shibasaki H, Yokokawa A, Furuta T, Abe K, Morita K, Tanaka S, Hirano T, Sakurai M, Mizuno K. Midazolam intoxication in a premature neonate. Clin Ther. 2020 in press
Xu W, Wu H, Chen S, Wang X, Tanaka S, Sugiyama K, Yamada H, Hirano T. Cytotoxic effects of vitamins K1, K2 and K3 against human T lymphoblastoid leukemia cells through apoptosis induction and cell cycle arrest. Chem Biol Drug Des. 96(4) 1134 - 1147 2020 doi 10.1111/cbdd.13696
Wencheng Xu, Xiaoqin Wang, Shuhe Chen, Hongguang Wu, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Tetrandrine enhances glucocorticoid receptor translocation possibly via inhibition of P-glycoprotein in daunorubicin-resistant human T lymphoblastoid leukemia cellsEuropean Journal of Pharmacology 881 173232 - 173232 2020
Xu W, Chen S, Wang X, Wu H, Yamada H, Hirano T. Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study. Bioorg Med Chem, 28:115553; 2020.
Xu Wencheng, Kusano J, Chen S, Yamamoto R, Matsuda H, Hara Y, Fujii Y, Hayashi S, Tanaka S, Sugiyama K, Yamada H, Hirano T.Absolute configuration of tetrandrine and isotetrandrine influences their anti-proliferation effects in human T cells via different regulation of NF-κB
Zeitschrift für Naturforschung C. 76(1-2) 21 - 25 2021 DOI 10.1515/znc-2020-0064
Yu B, Yuan B, Li JZ, Kiyomi A, Kikuchi H, Hayashi H, Hu X, Okazaki M, Sugiura M, HirYu B, Yuan B, Li JZ, Kiyomi A, Kikuchi H, Hayashi H, Hu X, Okazaki M, Sugiura M, Hirano T, Fan Y, Pei X, Takagi N. JNK and autophagy independently contributed to cytotoxicity of arsenite combined with tetrandrine via modulating cell cycle progression in human breast cancer cells. Frontiers in Pharmacology. 2020 in press
Endo M, Hirano R, Shibasaki H, Yokokawa A, Furuta T, Abe K, Morita K, Tanaka S, Hirano T, Sakurai M, Mizuno K. Midazolam Intoxication in a Premature Neonate. Case Reports Clin Ther 2020, 42(5):946-951.
Honma T, Onodera D, Horiguchi M, Sugiyama K, Hirano T. Influence of folic acid on suppressive efficacy of methotrexate against mitogen-activated human peripheral-blood mononuclear cells. Curr Top Pharmacol. 2020, 24: 49-60.
Xu W, Chen S, Wang X, Kusano J, Yamamoto R, Matsuda H, Hara Y, Fujii Y, Hayashi S, Tanaka S, Sugiyama K, Yamada H Hirano T. NF-κB regulation by bisbenzylisoquinoline alkaloids in human T cells : A structure-activity relationship study. Med Chem Res. 2020, 29(12):2123–2129. doi.org/10.1007/s00044-020-02624-2
Xu W, Yamada H, Hirano T. Methylprednisolone potentiates tetrandrine pharmacodynamics against human T lymphoblastoid leukemia MOLT-4 cells via regulation of NF-κB activation and cell cycle transition. Steroids 2020 in press
Xu W, Chen S, 4, Wang X, Wu H, Tahara K, Tanaka S, Sugiyama K, Yamada H, Sawada T, Hirano T. Effects of sinomenine on the proliferation, cytokineproduction and regulatory T-cell frequency in peripheralblood mononuclear cells of rheumatoid arthritis patients. Chem Biol Drug Des. 2020;96:1133–1146. doi 10.1002/ddr.21748
Kiyomi A, Miyakawa R, Matsumoto J, Yamazaki K, Imai S, Yuan B, Hirano T, Sugiura M. Potent antitumor activity of cepharanthine against triple‑negative breast cancer spheroids compared with tetrandrine. Oncology Letters 20: 331: 2020, doi 10.3892/ol.2020.12191
袁 博、岡崎真理、平野俊彦 ヒ素化合物の抗腫瘍活性およびその新規臨床応用の可能性 ファルマシア 56(5),421-425, 2020.
Xu W, Wang X, Tu Y, Masaki H, Tanaka S, Onda K, Sugiyama K, Yamada H, Hirano T.
Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells.
Chem Biol Interact 2019 310:108726. doi: 10.1016/j.cbi.2019.108726.
Pan C, Onda K, Hirano T.
Bevacizumab versus Anti-preeclamptic Drugs: Evaluation with Three-dimensionally Co-cultured Human Mini Tumors.
Anticancer Res. 2019 39: 3543-3551. doi: 10.21873/anticanres.13500
Zhao Y, Tanaka S, Yuan B, Sugiyama K, Onda K, Kiyomi A, Takagi N, Sugiura S, Hirano T.
Arsenic disulfide combined with L-buthionine-(S, R)-sulfoximine induces synergistic antitumor effects in two-dimensional and three-dimensional models of MCF-7 breast carcinoma cells.
Am J Chinese Med. 47(5): 1149-1170 2019
Xu W, Wang X, Tu Y, Masaki H, Tanaka S, Onda K, Sugiyama K, Yamada H, Hirano T.
Plant-derived alkaloid sinomenine potentiates glucocorticoid pharmacodynamics in mitogen-activated human peripheral blood mononuclear cells by regulating the translocation of glucocorticoid receptor.
Phytother Res. 33(1): 187-196 2019
Zhao Y, Onda K, Sugiyama K, Yuan B, Tanaka S, Takagi N, Hirano T.
Antitumor effects of arsenic disulfide on the viability, migratory ability, apoptosis and autophagy of breast cancer cells.
Oncol Rep. 41(1): 27-42 2019
Obara H, Morito N, Matsuno N, Yoshikawa R, Nakajo T, Gochi M, Otani M, Shonaka T, Furukawa H, Hirano T, Enosawa S.
Initial perfusate purification during subnormothermic machine perfusion for porcine liver donated after cardiac death. J Artif Organs. 23: 62–69 2020
Xu W, Meng K, Wu H, Miura T, Suzuki S, Chiyotanda M, Tanaka S, Sugiyama K, Kawashima H, Hirano T.
Vitamin K2 immunosuppressive effect on pediatric patients with atopic dermatitis.
Pediatr Int. 61: 1188-1195 2019
Bowen Yu, Bo Yuan, Anna Kiyomi, Hidetomo Kikuchi, Hideki Hayashi, Xiaomei Hu, Mari Okazaki, Munetoshi Sugiura, Toshihiko Hirano, Xiaohua Pei, Norio Takagi
Differentiation induction of human breast cancer cells by arsenite in combination with tetrandrine.
American Journal of Translational Research 2019 in press 11(12):7310-7323 2019.
1. 杉山健太郎、平野俊彦 臓器提供に関する薬学生の生前家族協議アンケート調査について
日本臨床腎移植学会雑誌 7(2) 156-160:2019
袁博,清海杏奈,平野俊彦 ヒ素化合物とテトランドリン併用の乳癌治療応用への可能性
メディカル・サイエンス・ダイジェスト ニューサイエンス社 45(8) 424-426:2019
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機械潅流が可能にする代謝に着目した移植のための臓器機能評価技術
Organ Biology 26(2):123-128:2019