研究室の業績

2021年度研究室の業績

原著

  1. Azuma K, Kawaguchi T, Yamaguchi T, Motegi S, Yamada K, Onda K, Iwase S, Unezaki S, Takeuchi H. Development of Japanese Versions of the Control Preferences Scale and Information Needs Questionnaire: Role of Decision-Making and Information Needs for Japanese Breast Cancer Patients. Patient Prefer Adherence. 2021;15:1017-1026
    https://doi.org/10.2147/PPA.S295383
  2. Xu W, Wu H, Tahara K, Chen S, Wang X, Tanaka S, Sugiyama K, Sawada T, Hirano T. Effects of vitamin K2 combined with methotrexate against mitogen‐activated peripheral blood mononuclear cells of healthy subjects and rheumatoid arthritis patients.  Fundamental & Clinical Pharmacology 35: 832-842 2021 doi.org/10.1111/fcp.12676
  3. Okihara M, Takeuchi H, Akiyama S, Yoshinaga S, Osato S, Akashi I, Kihara, Y, Iwamoto H, Oda T, Tanaka S, Unezaki S, Hirano T.  Pharmacodynamic drug-  drug interaction on human peripheral blood mononuclear cells between everolimus and tacrolimus at the therapeutic concentration range in renal transplantation.  Annals Transplant. 2021 in press
  4. Xu W, Chen S, Wang X, Tahara K, Wu H, Tanaka S, Sugiyama K, Sawada T, Hirano T.Suppressive effect of vitamin K2 against mitogen-activated peripheral blood mononuclear cells of rheumatoid arthritis patients. Int J Clin Pharmacol Ther. 59: 55 - 62 2021 doi.10.5414/cp203827
  5. Meiyu Zhang, Taro Miura, Shunsuke Suzuki, Masako Chiyotanda, Sachiko Tanaka, Kentaro Sugiyama, Hisashi Kawashima, Toshihiko Hirano. Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases. Biological and Pharmaceutical Bulletin 44(1) 7 - 17 2021 doi.org/10.1248/bpb.b20-00079
  6. Xu Wencheng, Kusano J, Chen S, Yamamoto R, Matsuda H, Hara Y, Fujii Y, Hayashi S, Tanaka S, Sugiyama K, Yamada H, Hirano T.Absolute configuration of tetrandrine and isotetrandrine influences their anti-proliferation effects in human T cells via different regulation of NF-κB  Zeitschrift für Naturforschung C. 2021 76(1-2)c: 21-25 DOI 10.1515/znc-2020-0064
  7. Xu W, Chen S, Wang X, Tanaka S, Onda K, Sugiyama K, Yamada H, Hirano T. Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases. Pharmacology & Therapeutics 217 107659 - 107659 2021 doi.org/10.1016/j.pharmthera.2020.107659
  8. Wencheng Xu, Hongguang Wu, Koichiro Tahara, Shuhe Chen, Xiaoqin Wang, Sachiko Tanaka, Kentaro Sugiyama, Tetsuji Sawada, Toshihiko Hirano. Effects of vitamin K2 combined with methotrexate against mitogen-activated peripheral blood mononuclear cells of healthy subjects and rheumatoid arthritis patients. Fundamental & Clinical Pharmacology 2021 in press
  9. Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Hongguang Wu, Koichiro Tahara, Sachiko Tanaka, Kentaro Sugiyama, Haruki Yamada, Tetsuji Sawada, Toshihiko Hirano. Effects of sinomenine on the proliferation, cytokine production, and regulatory T‐cell frequency in peripheral blood mononuclear cells of rheumatoid arthritis patients  Drug Development Research 82(2) 251 - 258 2021 doi.org/10.1002/ddr.21748

和文

1. 本間丈士, 亀山俊, 前田正輝, 堀口雅巳, 平野俊彦, 杉山健太郎　病院薬剤師と薬局薬剤師を対象とした関節リウマチ治療に関する意識調査 　応用薬理 101(1/2) 7-14 2021

2. Significance of 25-hydroxy vitamin D in early infants infected with respiratory syncytial virus.  Kusakawa G, Kashiwag Y, Abe Y, Tsusaka S, Sugiyama K, Sawada A, Kawashima H　Journal of Tokyo Medical University in press 2022

2020年度研究室の業績

原著

  1. Kanazawa H, Obara H, Yoshikawa R, Meng L, Hirano T, Okada Y, Nishikawa Y, Matsuno N. Impact of machine perfusion on sinusoid microcirculation of liver graft donated after cardiac death. J Surg Res 254:410-419; 2020

  2. Endo M, Hirano R, Shibasaki H, Yokokawa A, Furuta T, Abe K, Morita K, Tanaka S, Hirano T, Sakurai M, Mizuno K. Midazolam intoxication in a premature neonate. Clin Ther. 2020 in press

  3. Xu W, Wu H, Chen S, Wang X, Tanaka S, Sugiyama K, Yamada H, Hirano T. Cytotoxic effects of vitamins K1, K2 and K3 against human T lymphoblastoid leukemia cells through apoptosis induction and cell cycle arrest. Chem Biol Drug Des. 96(4) 1134 - 1147 2020 doi 10.1111/cbdd.13696

  4. Wencheng Xu, Xiaoqin Wang, Shuhe Chen, Hongguang Wu, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Tetrandrine enhances glucocorticoid receptor translocation possibly via inhibition of P-glycoprotein in daunorubicin-resistant human T lymphoblastoid leukemia cellsEuropean Journal of Pharmacology 881 173232 - 173232 2020

  5. Xu W, Chen S, Wang X, Wu H, Yamada H, Hirano T. Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study. Bioorg Med Chem, 28:115553; 2020.

  6. Xu Wencheng, Kusano J, Chen S, Yamamoto R, Matsuda H, Hara Y, Fujii Y, Hayashi S, Tanaka S, Sugiyama K, Yamada H, Hirano T.Absolute configuration of tetrandrine and isotetrandrine influences their anti-proliferation effects in human T cells via different regulation of NF-κB 
    Zeitschrift für Naturforschung C.  76(1-2) 21 - 25 2021 DOI 10.1515/znc-2020-0064

  7. Yu B, Yuan B, Li JZ, Kiyomi A, Kikuchi H, Hayashi H, Hu X, Okazaki M, Sugiura M, HirYu B, Yuan B, Li JZ, Kiyomi A, Kikuchi H, Hayashi H, Hu X, Okazaki M, Sugiura M, Hirano T, Fan Y, Pei X, Takagi N. JNK and autophagy independently contributed to cytotoxicity of arsenite combined with tetrandrine via modulating cell cycle progression in human breast cancer cells. Frontiers in Pharmacology. 2020 in press

  8. Endo M, Hirano R, Shibasaki H, Yokokawa A, Furuta T, Abe K, Morita K, Tanaka S, Hirano T, Sakurai M, Mizuno K. Midazolam Intoxication in a Premature Neonate. Case Reports Clin Ther  2020, 42(5):946-951.

  9. Honma T, Onodera D, Horiguchi M, Sugiyama K, Hirano T. Influence of folic acid on suppressive efficacy of methotrexate against mitogen-activated human peripheral-blood mononuclear cells. Curr Top Pharmacol. 2020, 24: 49-60.

  10. Xu W, Chen S, Wang X, Kusano J, Yamamoto R, Matsuda H, Hara Y, Fujii Y, Hayashi S, Tanaka S, Sugiyama K, Yamada H Hirano T. NF-κB regulation by bisbenzylisoquinoline alkaloids in human T cells : A structure-activity relationship study. Med Chem Res.  2020, 29(12):2123–2129. doi.org/10.1007/s00044-020-02624-2

  11. Xu W, Yamada H, Hirano T. Methylprednisolone potentiates tetrandrine pharmacodynamics against human T lymphoblastoid leukemia MOLT-4 cells via regulation of NF-κB activation and cell cycle transition.  Steroids 2020 in press

  12. Xu W, Chen S, 4, Wang X, Wu H, Tahara K, Tanaka S, Sugiyama K, Yamada H, Sawada T, Hirano T. Effects of sinomenine on the proliferation, cytokineproduction and regulatory T-cell frequency in peripheralblood mononuclear cells of rheumatoid arthritis patients. Chem Biol Drug Des. 2020;96:1133–1146. doi 10.1002/ddr.21748

  13. Kiyomi A, Miyakawa R, Matsumoto J, Yamazaki K, Imai S, Yuan B, Hirano T, Sugiura M.  Potent antitumor activity of cepharanthine against triple‑negative breast cancer spheroids compared with tetrandrine.  Oncology Letters 20: 331: 2020, doi 10.3892/ol.2020.12191

和文

　　　袁　博、岡崎真理、平野俊彦　ヒ素化合物の抗腫瘍活性およびその新規臨床応用の可能性　ファルマシア　56(5),421-425, 2020.

2019年度研究室の業績

原著

  1. Sugiyama K, Wada S, Tanaka S, Urai K, Hirano T.
    Effects of the tooth-coating solution and its components on the proliferation and production of inflammatory cytokines in mitogen-activated human peripheral blood mononuclear cells. 
    Curr Top Pharmacol. 23: 93-101 2019
     

  2. Xu W, Wang X, Tu Y, Masaki H, Tanaka S, Onda K, Sugiyama K, Yamada H, Hirano T.
    Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells.
    Chem Biol Interact 2019 310:108726. doi: 10.1016/j.cbi.2019.108726.  

  3. Pan C, Onda K, Hirano T.
    Bevacizumab versus Anti-preeclamptic Drugs: Evaluation with Three-dimensionally Co-cultured Human Mini Tumors. 
    Anticancer Res. 2019 39: 3543-3551. doi: 10.21873/anticanres.13500

  4. Zhao Y, Tanaka S, Yuan B, Sugiyama K, Onda K, Kiyomi A, Takagi N, Sugiura S, Hirano T.
    Arsenic disulfide combined with L-buthionine-(S, R)-sulfoximine induces synergistic antitumor effects in two-dimensional and three-dimensional models of MCF-7 breast carcinoma cells.
    Am J Chinese Med. 47(5): 1149-1170  2019

  5. Xu W, Wang X, Tu Y, Masaki H, Tanaka S, Onda K, Sugiyama K, Yamada H, Hirano T.
    Plant-derived alkaloid sinomenine potentiates glucocorticoid pharmacodynamics in mitogen-activated human peripheral blood mononuclear cells by regulating the translocation of glucocorticoid receptor.
    Phytother Res. 33(1): 187-196 2019

  6. Zhao Y, Onda K, Sugiyama K, Yuan B, Tanaka S, Takagi N, Hirano T.
    Antitumor effects of arsenic disulfide on the viability, migratory ability, apoptosis and autophagy of breast cancer cells.
    Oncol Rep. 41(1): 27-42 2019

  7. Obara H, Morito N, Matsuno N, Yoshikawa R, Nakajo T, Gochi M, Otani M, Shonaka T, Furukawa H, Hirano T, Enosawa S.  
    Initial perfusate purification during subnormothermic machine perfusion for porcine liver donated after cardiac death. J Artif Organs. 23: 62–69 2020

  8. Xu W, Meng K, Wu H, Miura T, Suzuki S, Chiyotanda M, Tanaka S, Sugiyama K, Kawashima H, Hirano T.
    Vitamin K2 immunosuppressive effect on pediatric patients with atopic dermatitis.
    Pediatr Int. 61: 1188-1195 2019

  9. Bowen Yu, Bo Yuan, Anna Kiyomi, Hidetomo Kikuchi, Hideki Hayashi, Xiaomei Hu, Mari Okazaki, Munetoshi Sugiura, Toshihiko Hirano, Xiaohua Pei, Norio Takagi
    Differentiation induction of human breast cancer cells by arsenite in combination with tetrandrine.
    American Journal of Translational Research 2019 in press  11(12):7310-7323 2019.

和文

     1. 杉山健太郎、平野俊彦　臓器提供に関する薬学生の生前家族協議アンケート調査について　
          日本臨床腎移植学会雑誌 7(2) 156-160：2019

著書

  1. 袁博，清海杏奈，平野俊彦　ヒ素化合物とテトランドリン併用の乳癌治療応用への可能性　
    メディカル・サイエンス・ダイジェスト　ニューサイエンス社　45(8) 424-426：2019

総説

　  1. 小原弘道、吉川 遼、松野直徒、中條哲也、絵野沢伸、平野俊彦　
         機械潅流が可能にする代謝に着目した移植のための臓器機能評価技術
         Organ Biology 26(2):123-128：2019

平成30年度臨床薬理学教室卒論発表会について

平成30年度臨床薬理学教室卒論発表会を行いました。皆教室員一同質疑応答を行っていました。

IMG_36312018.8.7.jpg

 

2018年度研究室の業績

原著

  1. Yuxue Zhao, Bo Yuan, Kenji Onda, Kentaro Sugiyama, Sachiko Tanaka, Norio Takagi, and Toshihiko Hirano
    Anticancer Efficacies of Arsenic Disulfide through Apoptosis Induction, Cell Cycle Arrest, and Pro-survival Signal Inhibition in Human Breast Cancer Cells　
    Am J Cancer Res. 8, 366-386 (2018) 
     
  2. Junichi Kusano*,  Sachiko Tanaka, Hiroto Matsuda*, Yoshikazu Hara*,  Yoshiaki Fujii*,  Shinya Suzuki*, Masao Sekiyama*, Eiki Ando*,　 Kentaro Sugiyama, and Toshihiko Hirano
    Vitamin K1 and K2 Immunopharmacological Effects on the Peripheral Lymphocytes of Healthy Subjects and Dialysis Patients, As Estimated by the Lymphocyte Immunosuppressant Sensitivity Test 
    J Clin Pharm Ther. 43, 895-902 (2018)　
     
  3. Kehan Meng, Wencheng Xu*1, Taro Miura*2, Shunsuke Suzuki*3, Masako Chiyotanda*2,  Sachiko Tanaka, Kentaro Sugiyama, Hisashi Kawashima*2, and Toshihiko Hirano
    The Effects of Vitamin K1 and Vitamin K2 on the Proliferation, Cytokine Production and Regulatory T-cell Frequency in Peripheral Blood Mononuclear Cells of Paediatric Atopic Dermatitis Patients 
    Exp Dermatol. 27, 1058-1060 (2018) 
     
  4. Yuxue Zhao, Kenji Onda, Bo Yuan, Sachiko Tanaka, Anna Kiyomi, Kentaro Sugiyama, Munetoshi Sugiura, Norio Takagi, and Toshihiko Hirano
    Arsenic Disulfide‑induced Apoptosis and Its Potential Mechanism in Two‑ and Three‑dimensionally Cultured Human Breast Cancer MCF‑7 Cells　
    Int J Oncol, 52, 1959-1971 (2018) 
     
  5. Masayuki Masuda＊1, Hiroya Utsumi*2 , Sachiko Tanaka, Akemi Maeno, MamikoYamamoto, Kentaro Sugiyama, Toshihiko Hirano, and Hitoshi Aizawa＊1
    Treatment of Myasthenia Gravis with High-dose Cholinesterase Inhibitors and Calcineurin Inhibitors Caused Spontaneous Muscle Cramps in Patients　
    Clin Neuropharmacol, 41, 164-170 (2018)　
     
  6. Nami Uematsu, Yuxue Zhao, Anna Kiyomi, Bo Yuan, Kenji Onda,  Sachiko Tanaka, Kentaro Sugiyama, Munetoshi Sugiura, Norio Takagi,  Akemi Hayakawa＊, and Toshihiko Hirano
    Chemo-sensitivity of Two-dimensional Monolayer and Three-dimensional Spheroid of Breast Cancer MCF-7 Cells to Daunorubicin, Docetaxel, and Arsenic Disulfide 
    Anticancer Res, 38, 2101-2108 (2018) 
     
  7. Bo Yuan, Mingjiang Yao*1, Xiao Wang, Ai Sato, Ayane Okazaki,  Hana Komuro, Hideki Hayashi, Hiroo Toyoda, Xiaohua Pei*2,　Xiaomei Hu*1, Toshihiko Hirano, and Norio Takagi Antitumor Activity of Arsenite in Combination with Tetrandrine against Human Breast Cancer Cell Line MDA-MB-231 in vitro and in vivo 
    Cancer Cell Int, 18, 113 (2018). 

2017年度研究室の業績

原著

  1. Kameyama S, Kase Y, Saito M, Kurihara S, Yoshida F, Noda M, Iiduka T, Horiguchi M, Sugiyama K, Hirano T. Influence of high-dose folic acid on methotrexate efficacies and safety in Japanese rheumatoid arthritis patients. Drug Res 67:(12) 705-709 2017

  2. Xu W, Meng K, Kusano J, Matsuda H, Hara Y, Fujii Y, Suzuki S, Ando E, Wang X, Tu Y, Tanaka S , Sugiyama K, Yamada H, Hirano T. Immunosuppressive efficacy of tetrandrine combined with methylprednisolone against mitogen-activated peripheral blood mononuclear cells of hemodialysis patients Clin Exp Pharmacol Physiol 44:(9) 924-931 2017

  3. Yao M, Yuan B, Wang X, Sato A, Sakuma K, Kaneko K, Komuro H, Okazaki A, Hayashi H, Toyoda H, Pei X, Hu X, Hirano T, Takagi N.　 Synergistic cytotoxic effects of arsenite and tetrandrine in human breast cancer cell line MCF-7. Int J Oncol 51(2):587-598 2017

  4. Xu W, Meng K, Tu Y, Tanaka S, Onda K, Sugiyama K, Hirano T, Yamada H. Tetrandrine potentiates the glucocorticoid pharmacodynamics via inhibiting P-glycoprotein and mitogen-activated protein kinase in mitogen-activated human peripheral blood mononuclear cells.  Eur J Pharmacol 807(15) 102-108 2017

  5. Sugiyama K, Tsukaguchi M, Kusano J, Isogai K, Sasahara H, Suzuki N, Toyama A, Nakagawa Y, Saito K, Takahashi K, Hirano T. A comparative study of the ATP concentrations in the peripheral CD4+ lymphocytes of living donor and cadaveric donor renal transplant recipients. Curr Top Pharmacol 21: 27-33 2017

  6. Onda K, Tong S, Beard S, Binder N, Muto M, Senadheera SN, Parry L, Dilworth M, Renshall L, Brownfoot F, Hastie R, Tuohey L, Palmer K, Hirano T, Ikawa M, Kaitu’u-Lino T, and Hannan NJ. Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction. Hypertension 69, 457-468.  2017 doi: 10.1161/HYPERTENSIONAHA.116.08408.

  7. Hannan NJ, Beard S, Binder N, Onda K, Kaitu’u-Lino T, Chen Q, Tuohey L, De Silva M, Tong S.　Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction. 　Placenta 2017 doi.org/10.1016/j.placenta.2017.01.002

  8. Kusano J, Kato R, Matsuda H, Hara Y, Yoshiaki Fujii Y, Suzuki S, Sekiyama M, Ando E, Sugiyama K, Hirano T.  The evaluation of the infection risk in dialysis and chronic kidney disease patients using an ATP monitoring assay. Ther Apher Dial. 21; 3: 270-278  2017

和文

  1. 杉山健太郎、平野俊彦臓器提供に関する薬学生の意識調査について 日本臨床腎移植学会雑誌 5:(1) 23-27 2017
  2. 森井湧太、松野直徒、森戸規之、絵野沢伸、平野俊彦、古川博之、小原弘道 心停止ドナーからのブタ腎保存における酸素化復温灌流保存方法の有用性の研究 移植  53:（1）2017 in press

  3. 竹内裕紀, 市田公美,虎石竜典,岩本整,中村有紀,今野理,木原優,横山卓剛,池田千絵,奥山清,川口崇,河地茂行,尾田高志,平野俊彦,畝崎 榮 アザチオプリンとアロプリノールの併用は禁忌とすべきではないか　古くて新しい課題-新規尿酸合成阻害薬の比較および自験例から考える-　痛風と核酸代謝 41(2) 116-117

著書

  1. 杉山健太郎　薬学と社会―医療経済・多職種連携とチーム医療・地域医療・在宅医療 (臨床薬学テキストシリーズ)　(担当:共著, 範囲:移植チーム) 中山書店   2017　90-94

2016年度研究室の業績

原著

  1. Usui K, Okubo Y,  Hirano T, Tsuboi R.　Vitamin D3 derivatives, alone or in combination with glucocorticoids, suppress streptococcal pyrogenic enterotoxin A-stimulated proliferation of peripheral blood mononuclear cells (PBMCs) in patients with psoriasis. J Dermatol 2016 in press 

  2. Yuan B, Jing H, Kisoh K, Hayashi H, Tanaka S, Si N, Zhao H, Hirano T, Bian B, Takagi N. Effects of active bufadienolide compounds on human cancer cells and CD4+CD25+Foxp3+ regulatory T cells in mitogen-activated human peripheral blood mononuclear cells. Oncology Reports 2016, DOI: 10.3892/or.2016.4946

  3. Shuiling C, Sugiyama K, Inamura M, Tanaka S, Onda K, Huijun Y, Hirano T. Effects of insulin on pharmacodynamics of immunosuppressive drugs against mitogen-activated human peripheral-blood mononuclear cells. Immunopharmacol Immunotoxicol.  38(5) 372-378 2016

2015年度研究室の業績

原著

  1. Tong S*, Kaitu’u-Lino TJ*, Onda K, Beard S, Hastie R, Binder NK, Cluver C, Tuohey L, Whitehead, C., Brownfoot F, Silva MD, Hannan NJ. Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion. Hypertension　Published online before print August 31, 2015,doi: 10.1161/HYPERTENSIONAHA.115.0584 (*denotes equal contribution)

  2. Song M, Fang S, Tanaka S, Sugiyama K, Kiyomi A, Kato R, Onda K, Yuan B, Takagi N, Hu X, Hirano T. Effects of arsenic disulfide on proliferation, cytokine production, and frequencies of CD4+, CD8+, and regulatory T cells in mitogen-activated human peripheral blood mononuclear cells.  Int Immunopharmacol 2015, 29: 832-838 doi:10.1016/j.intimp.2015.08.034

  3. Nakaoka E, Tanaka S, Onda K, Sugiyama K, Hirano T.  Effects of Vitamin K3 and K5 on Daunorubicin-Resistant Human T Lymphoblastoid Leukemia Cells. Anticancer Res 2015, 35: 6041-6048

  4. Brownfoot F, Tong S, Hannan N, Binder N, Walker SP, Cannon P, Hastie R, Onda K, Kaitu’u-Lino TJ. Effects of Pravastatin on Human Placenta, Endothelium, and Women with Severe Preeclampsia. Hypertension. HYPERTENSIONAHA.115.05445 Published online before print July 27, 2015, doi:10.1161/HYPERTENSIONAHA.115.05445 (2015)

  5. Kiyomi A, Makita M, Ozeki T, Li N, Satomura A, Tanaka S, Onda K, Sugiyama K, Iwase T, Hirano T. Characterization and clinical implication of Th1/Th2/Th17 cytokines produced from three-dimensionally cultured tumor tissues resected from breast cancer patients. Translational Oncology 2015, 8: 318-326

  6. Nakamura Y, Hayakawa A, Ishizawa H, Kamei Y, Tanaka S, Onda K, Sugiyama K, Hirano T. Immunomodulatory effects of the pentapeptide YGSRS on human peripheral-blood mononuclear cells. Immunopharmacol Immunotoxicol 2015, 37: 318-323 DOI: 10.3109/08923973.2015.1038752

  7. Yuan B, Okusumi S, Yoshino Y, Moriyama C, Tanaka S, Hirano T, Takagi N, Toyoda H. Delphinidin induces cytotoxicity and potentiates cytocidal effect in combination with arsenite in an acute promyelocytic leukemia cell line, NB4. Oncology Report 34(1):431-438 2015

  8. Sugiyama K, Tsukaguchi M, Sasahara H, Isogai K, Toyama A, Satoh H, Saito K, Nakagawa Y, Takahashi K, Tanaka S, Onda K, Hirano T. Relationship between the peripheral lymphocyte response to mycophenolic acid in vitro and the level of ATP in peripheral CD4+ lymphocytes before and after renal transplantation. Drug Research 2015, 65: 629-634

和文

  1. 抗リウマチ薬イグラチモドの副作用発現に関わる患者因子の検討　亀山俊、栗原沙織、飯塚敏美、堀口雅巳、平野俊彦　日本薬剤師会雑誌 2016; 68：1863-1867

著書

Yuan B, Iriyama N, Hu XM, Hirano T, Toyoda H, Takagi N.  Perspective on therapeutic strategies of leukemia treatment: focus on arsenic compounds.  Leukemia – Various Types, InTech Co. Ltd. 2015 in press.

監修

杉山健太郎 薬がみえる  Vol.2 メディックメディア 2015年7月 

2014年度研究室の業績

原著

  1. Takeuchi H, Iwamoto H, Nakamura Y, Hirano T, Konno O, Kihara Y, Chiba N, Yokoyama K, Takano　K, Toraishi T, Okuyama K, Ikeda C, Tanaka S, Onda K, Soga A, Kikuchi Y, Kawaguchi T, Kawachi S, Unezaki S, Shimazu M. Synergistic effects of calcineurin inhibitors and steroids on steroid sensitivity of peripheral blood mononuclear cells. Cell Medicine, DOI: 10.3727/215517914X681802; 2015

  2. Onda K, Tong S, Nakahara A, Kondo M, Monchusho H, Hirano T, Kaitu’u-Lino T, Beard S, Binder N, Tuohey L, Brownfoot F, Hannan NJ. Sofalcone up-regulates hemeoxygenase-1 via nuclear factor (erythroid-derived 2)-like 2, reduces sFlt-1 & quenches endothelial dysfunction: a potential therapeutic for preeclampsia. Hypertension.2015;65:855-862,　doi:10.1161/HYPERTENSIONAHA.114.04781（本論文はClinical Implication欄に掲載されました。Hypertension. 2015;65:697, doi:10.1161/HYPERTENSIONAHA.115.05374）

  3. Kiyomi A, Makita M, Iwase T, Tanaka S, Onda K, Sugiyama K, Takeuchi H, Hirano T. Clinical Significance of Female-hormones and Cytokines in Breast Cancer Patients Complicated with Aromatase Inhibitor-related Osteoarthropathy ? Efficacy of Vitamin E. J Cancer. 2014; 6: 367-376

  4. Kaitu’u-Lino TJ, Tong S, Beard S, Hastie R, Tuohey L, Brownfoot F, Onda K, Hannan NJ. Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin. Pregnancy Hypertension doi.org/10.1016/j.preghy.2014.09.003

  5. Sakai C, Arai M, Tanaka S, Onda K, Sugiyama K, Hirano T. Effects of Arsenic Compounds on Growth, Cell- Cycle Distribution, and Apoptosis of Tretinoin-Rresistant Human Promyelocytic Leukemia Cells. Anticancer Res 2014; 35: 6489-6494

  6. Brownfoot FC, Hannan N, Onda K, Tong S, Kaitu’u-Lino T. Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells. Placenta 2014 ;35:724-31. doi: 10.1016/j.placenta.2014.06.374.

  7. Tahata S, Yuan B, Kikuchi H, Takagi N, Hirano T, Toyoda H. Cytotoxic effects of pyrrolidine dithiocarbamate in small-cell lung cancer cells, alone and in combination with cisplatin. Int J Oncol 45(4):1749-1759 2014

  8. Muhetaer G, Takeuchi H, Unezaki S, Kawachi S, Iwamoto H, Nakamura Y, Shimazu M, Sugiyama K, Hirano T. Clinical significance of peripheral-blood lymphocyte sensitivity to glucocorticoids for differentiation of high risk patients accompanying decreased allograft function after glucocorticoid withdrawal in renal transplantation. Clinical Therapeutics 2014; 36:1264-1272

  9. Hatanaka H, Ishizawa H, Nakamura Y, Tadokoro H, Tanaka S, Onda K, Sugiyama K, Hirano T. Effects of vitamin K3 and K5 on proliferation, cytokine production, and regulatory T cell-frequency in human peripheral-blood mononuclear cells. Life Sciences 2014; 99:61-68.

  10. Sugiyama K, Tsukaguchi M, Sasahara S, Isogai K, Toyama A, Satoh H, Saito K, Nakagawa Y, Takahashi K, Tanaka S, Onda K,Hirano T. Clinical significance of immune monitoring by the lymphocyte ATP assay in renal transplant recipients treated with a calcineurin inhibitor. Exp Clin Transplant. 2014; 3:195-199

  11. Matsuno N, Obara H, Watanabe R, Iwata S, Kono S, Fujiyama M, Hirano T, Kanazawa H, Enosawa S. Rewarming preservation by organ perfusion system for donation after cardiac death liver grafts in pigs. Transplant Proc. 2014; 46:1095-1098.

和文

  1. 末梢リンパ球の免疫抑制薬剤感受性試験におけるIC50値とボトム値の関連について 塚口真穂登、笹原浩康、杉山健太郎、磯貝和也、外山　聡、佐藤　博、齋藤和英、中川由紀、高橋公太、田中祥子、恩田健二、平野俊彦 Organ Biology 2014; 21:260-264

  2. ヒト末梢血単核細胞からのサイトカイン産生に対する抗生物質バリノマイシン、アジスロマイシンおよびニゲリシンの抑制効果 杉山健太郎、石澤瞳、中村友利恵、恩田健二、田中祥子、平野俊彦 Organ Biology 2014; 21:265-270

総説論文

  1. 腎移植にかかわる医療従事者の役割と最新の知識ｰ薬剤師の役割ｰ 杉山健太郎 腎と透析 2015; 78: 55-59 

  2. 平成25年度日本臓器保存生物医学会研究奨励賞　受賞記念講演(Review Article) ABO不適合腎移植患者の脱感作療法開始時および移植直前の免疫抑制薬感受性と個別医療 杉山健太郎、笹原浩康、磯貝和也、塚口真穂登、外山 聡、佐藤 博、齋藤和英、中川由紀、高橋公太、田中祥子、恩田健二、平野俊彦 Organ Biology 2014; 21:182-186 

2013年度研究室の業績

原著

  1. Obara H, Matsuno N, Shigeta T, Enosawa S, Hirano T, Mizunuma H. Rewarming machine perfusion system for liver transplantation. Journal of Medical Device. 2013 in press 7(4), 041011 (Oct 25, 2013)doi:10.1115/1.4025189

  2. Hu XM, Yuan B, Tanaka S, Song MM, Onda K, Tohyama K, Zhou AX, Toyoda H, Hirano T. Arsenic disulfide-triggered apoptosis and erythroid differentiation in myelodysplastic syndrome and acute myeloid leukemia cell lines. Hematology 2013, Nov.14, DOI: http://dx.doi.org/10.1179/1607845413Y.0000000138.

  3. Sasahara H, Sugiyama K, Tsukaguchi M, Isogai K, Toyama A, Satoh H, Saitoh K, Nakagawa Y, Takahashi K, Tanaka S, Onda K, Hirano T. Comparison of the pharmacological efficacies of immunosuppressive drugs evaluated by the ATP production and mitochondrial activity in human lymphocytes. Cell Medicine. 2013; 6:39-45.

  4. Sugiyama K, Sasahara H, Tsukaguchi M, Isogai K, Toyama A, Satoh H, Saitoh K, Nakagawa Y, Takahashi K, Tanaka S, Onda K, Hirano T. Peripheral lymphocyte-response to mycophenolic acid in vitro and incidence of cytomegalovirus infection in renal transplantation. Cell Medicine. 2013; 6:47-55.

  5. Hu XM, Tanaka S,Onda K, Yuan B, Toyoda H, Ma R, Liu F, Hirano T. Arsenic disulfide induced apoptosis and concurrently promoted erythroid differentiation in cytokine-dependent MDS-progressed leukemia cell line F-36p with complex karyotype including monosomy 7. Chinese Journal of Integrative Medicine 2013, DOI: 10.1007/s 11655-013-1514-7.

  6. Obara H, Matsuno N, Shigeta T, Enosawa S, Hirano T, Mizunuma H. Rewarming machine perfusion system for liver transplantation. Journal of Medical Devices, 2013 7(4), 041011 (Oct 25, 2013) doi:10.1115/1.4025189

  7. Hu XM, Yuan B, Tanaka S, Zhou Q, Onda K, Toyoda H, Hirano T. Involvement of oxidative stress associated with glutathione depletion and p38 mitogen-activated protein kinase activation in arsenic disulfide-induced differentiation in HL-60 cells. Leuk Lymphoma. 2013 55:392-404.

  8. Kikuchi H, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H. Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines. Int J Oncol. 2013;43:1976-1984.

  9. Tadokoro H, Umezu T, Ohyashiki K, Hirano T, Ohyashiki J. Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells. J Biol Chem. 2013; 288: 34343-34351.

  10. Obara H, Matsuno N, Shigeta T, Hirano T, Enosawa S, Mizunuma H. Temperature controlled machine perfusion system for liver. Transplant Proc. 45; 1690?1692: 2013.

  11. Tohyama N, Tanaka S, Onda K, Sugiyama K, Hirano T. Influence of anticancer agentson cell survival, proliferation, and CD4+CD25+Foxp3+ regulatory T cell-frequency in human peripheral-blood mononuclear cells activated by T cell-mitogen. Int Immunopharmacol. 2013; 15: 160-166

  12. Onda K, Horike N, Suzuki T, Hirano T. Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes. Phytother Res. 2013; 27:312-316.

  13. Hu XM, Yuan B, Song MM, Onda K, Tanaka S, Toyoda H, Zhou AX, Sugiyama K, Hirano T. Dose-dependent biphasic effects of arsenic disulfide on differentiation and apoptosis of HL-60 cells. Current Topics in Pharmacology 2013; 17:13-25

和文

  1. 磯貝和也、荒川圭子、外山　聡、佐藤　博、齋藤和英、中川由紀、杉山健太郎、高橋公太　小児腎移植患者への薬剤管理指導に関する検討　日本臨床腎移植学会雑誌 2013; 1: 209-213

  2. 杉山健太郎、笹原浩康、磯貝和也、塚口真穂登、外山 聡、佐藤 博、齋藤和英、中川由紀、高橋公太、田中祥子、恩田健二、平野俊彦　腎移植前、および移植２、４、６週後における末梢血リンパ球のシクロスポリンおよびタクロリムス感受性の相関性　Organ Biology 2013; 20: 11-17

著書

  1. 平野俊彦　イラストでみる　疾患と薬物治療　医学評論社 2013; 384-434

  2. 平野俊彦　各種治療の予後予測の面からみたバイオマーカーの探索と開発（患者末梢血リンパ球の増殖能とステロイド感受性に基づく敗血症発症リスク予測の可能性）第２章：敗血症のバイオマーカーの開発　技術情報協会 2013; 159-162

2012年度研究室の業績

原著

  1. Yokoyama H, Ebara M, Nakamura F, Nanasawa A, Tanaka S, Onda K, Sugiyama K, Kasuya K, Muhetaer G, Shimazu M, Hirano T. Rapid and simple analysis of N-aspartylchlorin e6 (talaporfin) using fluorescence microtiterplate and its application for determination in cells, tissues and blood. J Cancer Ther 2012; 3: 521-527.

  2. Toraishi T, Takeuchi H, Nakamura Y, Konno O, Yokoyama T, Iwamoto H, Hama K, Hirano T, Unezaki S, Okuyama K, Shimazu M. Falsely abnormally elevated blood trough concentration of tacrolimus measured by antibody-conjugated magnetic immunoassay in a renal transplant recipient: a case report. Transplant Proc. 2012; 44:134-136

  3. Onda K, Suzuki R, Tanaka S, Oga H, Oka K, Hirano T. Decitabine, a DNA methyltransferase inhibitor, reduces P-glycoprotein mRNA and protein expressions and increases drug sensitivity in drug-resistant MOLT4 and Jurkat cell lines. Anticancer Res. 2012; 32:4439-4444.

  4. Sugiyama K, Isogai K, Horisawa S, Toyama A, Satoh H, Saito K, Nakagawa Y, Tasaki M, Takahashi K, Hirano T. Comparative study of the cellular pharmacodynamics of tacrolimus in renal transplant recipients treated with and without basiliximab. Cell Transplant. 2012; 21:565-570.

  5. Ito S, Masuda M, Tanaka S, Takagi M, Tanaka C, Yamada N, Nakajima K, Akashi T, Hirano T, Utsumi H. Low-dose glucocorticoid therapy complements the pituitary-adrenocortical system and reduces anxiety and insomnia in myasthenia gravis patients. Clin Neuropharmacol. 2012; 35:30-36.

  6. Ishibashi M, Arai M, Tanaka S, Onda K, Hirano T. Antiproliferative and apoptosis-inducing effects of lipophilic vitamins on human melanoma A375 cells in vitro. Biol Pharm Bull. 2012; 35:10-17.

  7. Muhetaer　G, Takeuchi H, Akizuki S, Unezaki S, Iwamoto H, Shimazu M, Hirano T. Higher sensitivity of peripheral blood lymphocytes to endogenous glucocorticoid in renal transplant recipients treated with tacrolimus as compared to those treated with cyclosporine. Cell Medicine 2012; 3:75-80.

  8. Sugiyama K, Isogai K, Toyama A, Satoh H, Saito K, Nakagawa Y, Tasaki M, Takahashi K, Hirano T. Tacrolimus pharmacological efficacy estimated by lymphocyte immunosuppressant sensitivity test (LIST) before and after renal transplantation. Cell Medicine 2012; 3:81-88.

和文

  1. 笹原浩康、杉山健太郎、磯貝和也、塚口真穂登、外山 聡、佐藤 博、齋藤和英、中川由紀、高橋公太、平野俊彦　メチルプレドニゾロンコハク酸エステルナトリウムの先発医薬品と後発医薬品間のリンパ球増殖抑制効果の比較　Organ Biology 2012; 19:103-106.

  2. 血液透析患者へのバルガンシクロビルの投与量設定に薬剤師が関与した一症例　磯貝和也、 杉山健太郎、坂爪重明、外山聡、佐藤博、齋藤和英、中川由紀、高橋公太　医薬ジャーナル 2012; 48:1541-1546.

総説論文

  1. 杉山健太郎、佐藤　博、平野俊彦　免疫抑制薬の感受性試験による腎移植前後の薬効評価 シクロスポリン、タクロリムス、ミコフェノール酸の感受性測定から　今日の移植　2012; 25:11-15.

  2. 松野直徒、小原弘道、武藤眞、平野俊彦、水沼博、絵野沢伸 心停止ドナーからの肝移植における持続潅流保存の研究　　Organ Biology 2012; 19:80－82.

著書

  1. 磯貝和也、杉山健太郎、荒川圭子、外山 聡、佐藤 博、齋藤和英、中川由紀、田邉真弓、高橋公太 献腎移植患者におけるファーマシューティカルケアの考察について 第45回日本臨床腎移植学会記録集　腎移植症例集2012　高橋公太編, 日本医学館

2011年度研究室の業績

原著

  1. Ishibashi M, Arai M, Tanaka S, Onda K, Hirano T. Antiproliferative and Apoptosis-Inducing Effects of Lipophilic Vitamins on Human Melanoma A375 Cells in vitro Biol. Pharm. Bull., 2011; 35: 10-17.

  2. Hikita E, Arai M, Tanaka S, Onda K, Utsumi H, Yuan B, Toyoda H, Hirano T. Effects of Inorganic and Organic Arsenic Compounds on Growth and Apoptosis of Human T-Lymphoblastoid Leukemia Cells. Anticancer Res. 2011; 31: 4169-4178.

  3. Hiwatashi Y, Maeda M, Fukushima H, Onda K, Tanaka S, Utsumi H, Hirano T. Azithromycin Suppresses Proliferation, Interleukin Production and Mitogen-activated Protein Kinases in Human Peripheral-blood Mononuclear Cells Stimulated with Bacterial Superantigen J. Pharm. Pharmacol. 2011; 63: 1320-1326.

  4. Hiwatashi Y, Tadokoro H, Henmi K, Arai M, Kaise T, Tanaka S, Hirano T. Antiproliferative and Anti-invasive Effects of Inorganic and Organic Arsenic Compounds on Human and Murine Melanoma cells in vitro J. Pharm. Pharmacol, 2011; 63: 1202-1210.

  5. Maeda M, Tanaka S, Ishizawa H, Nakamura Y, Onda K, Hirano T. Suppressive Effects of Peptide Antibiotics against Proliferation and Cytokine Production in Mitogen-Activated Human Peripheral-blood Mononuclear Cells Arzneimittelforschung, 2011; 61: 1-15.

  6. Sugiyama K, Isogai K, Toyama A, Satoh H, Saito K, Nakagawa Y, Tasaki M, Takahashi K, Hirano T. Correlation between the pharmacological efficacy of cyclosporine and tacrolimus as evaluated by the lymphocyte immunosuppressant sensitivity test (LIST) and the MTT assay procedure in patients before and after renal transplantation. Int J Clin Pharmacol Ther. 2011; 49: 145-152.

  7. Takeuchi H, Matsuno N, Hirano T, Gulimire M, Hama K, Nakamura Y, Iwamoto H, Toraishi T, Kawaguchi T, Okuyama K, Unezaki S, Nagao T Steroid withdrawal based on lymphocyte sensitivity to endogenous steroid in renal transplant recipients. Biol Pharm Bull 34:1578-83; 2011.

  8. Yoshino Y, Yuan B, Kaise T, Takeuchi M, Tanaka S, Hirano T, Kroetz DL, Toyoda H. Contribution of aquaporin 9 and multidrug resistance-associated protein 2 todifferential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes. Toxicol Appl Pharmacol 257: 198-208; 2011.

和文

  1. 臨床応用を目指した肝移植用持続灌流保存装置の開発と温阻血障害肝を用いた研究 松野直徒、小原弘道、平野俊彦、武藤眞、許懐哲、絵野沢伸、水沼 博 Organ Biology 2011; 18: 87-91.

  2. 肝移植用持続灌流保存装置の開発　松野直徒、小原弘道、平野俊彦、武藤眞、水沼博、絵野沢伸 今日の移植 2011; 24: 269-275.

総説

  1. 腎移植患者に対する薬剤師業務 免疫抑制薬の感受性試験と服薬指導 杉山健太郎、磯貝和也、坂爪重明、外山 聡、佐藤 博、齋藤和英、中川由紀、田崎正行、高橋公太、平野俊彦 Organ Biology 2011; 18: 47-51.

  2. 平野　俊彦　副腎皮質ステロイドの体内動態 関節外科. 2011; 30: 21-24.

  3. 平野　俊彦　生体内鉄と臓器障害 Organ Biology，2011; 18: 151-152.

2010年度研究室の業績

原著

  1. Sugiyama K, Isogai K, Horisawa S, Toyama A, Satoh H, Saito K, Nakagawa Y, Tasaki M, Takahashi K, Hirano T. The pharmacological efficacy of mycophenolic acid before and after renal transplantation as estimated by the lymphocyte immunosuppressant sensitivity test (LIST). Immunopharmacol Immunotoxicol. 2010;32:430- 436.

  2. Masuda M, Matsumoto M, Tanaka S, Nakajima K, Yamada N, Ido N, Ohtsuka T, Nishida M, Hirano T, Utsumi H. Clinical implication of peripheral CD4+CD25+ regulatory T cells and Th17 cells in myasthenia gravis patients. J Neuroimmunol. 2010;225:123-131.

  3. Shibuya A, Onda K, Kawahara H, Uchiyama Y, Nakayama H, Omi T, Nagaoka M, Matsui H, Hirano T. Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme- oxygenase-1 dependent pathway in gastric epithelial cells. Biochem Biophys Res Commun. 2010;398:581- 584.

  4. Ishii K, Tanaka S, Kagami K, Henmi K, Toyoda H, Kaise T, Hirano T. Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin- resistant T lymphoblastoid leukemia cells. Cancer Invest. 2010;28:220-229.

  5. Masuda M, Tanaka S, Nakajima K, Yamada N, Ido N, Ohtsuka T, Nishida M, Hirano T, Utsumi H. Clinical implications of the type 1/type 2 balance of helper T cells and P-glycoprotein function in peripheral T lymphocytes of myasthenia gravis patients. Eur J Pharmacol. 2010;627:325-331.

  6. Ashizawa T, Iwahori T, Yokoyama T, Kihara Y, Konnno O, Jyojima Y, Akashi I, Nakamura Y, Hama K, Iwamoto H, Segawa M, Takeuchi H, Hirano T, Nagao T. Irinotecan hydrochloride (CPT-11) in dialysis patients with gastrointestinal cancer. Acta Med Okayama. 2010 ;64:19-426.

  7. Maeda M, Ishii H, Tanaka S, Onda K, Hirano T. Suppressive efficacies of antimicrobial agents against human peripheral- blood mononuclear cells stimulated with T cell mitogen and bacterial superantigen. Arzneimittelforschung. 2010;60:760-768.

総説

  1. 平野俊彦 医師と薬剤師が共有すべき薬の新知識 Organ Biology, 17, 265−273（2010）

  2. 平野俊彦 肝移植における末梢血リンパ球のタクロリムス感受性に基づくテーラーメード療法の確立 薬学研究の進歩，27，97−102（2011）

学会発表記録

国際学会
70th International Congress of FIP

2010 年8 月　於　Lisbon, Portugal
S. Tanaka, H. Utsumi, M. Masuda, Y. Morisaki, K. Onda, H. Takeuchi, S. Unezaki, T. Akashi, N. Ido, T. Ohtsuka, M. Nishida, and T. Hirano
  The expression of costimulatory molecules of peripheral lymphocytes in myasthenia gravis patients who treated with immunosuppressive drugs

国内学会
第7 回　ヘムオキシゲナーゼ研究フォーラム

2010 年8 月　於　京都
恩田　健二，澁谷　陽子，松井　裕史，平野　俊彦
  胃上皮細胞において消化性潰瘍治療薬ソファルコンはNrf2?HO?1 経路を介してVEGF産生を促進する

第54 回　日本薬学会関東支部大会

2010 年10月　於　東京
恩田　健二，澁谷　陽子，川原　大史，内山　祐佳，中山　裕子，大見　貴正，長岡　成佳，平野　俊彦
  胃粘膜防御因子増強薬ソファルコンの胃上皮細胞におけるVEGF 産生効果― Nrf2?HO?1経路の関与―

下平　智秀，田中　祥子，高坂　　聡，明石　真和，吉川　憲子，中林　　巌，吉田　雅治，白井小百合，明石　貴雄，平野　俊彦
  微小変化型ネフローゼ症候群患者末梢血単核細胞における免疫抑制薬感受性と治療応答性との関連

第31 回　日本臨床薬理学会年会

2010 年12月　於　京都
恩田　健二，澁谷　陽子，川原　大史，内山　祐佳，中山　裕子，大見　貴正，長岡　成佳，平野　俊彦
  消化性潰瘍治療薬ソファルコンは胃上皮細胞においてNrf2?HO?1 経路を介してVEGF産生を促進する

田中　祥子，増田　眞之，高木　美和，松本　　萌，井戸　信博，伊藤　　傑，内海　裕也，平野　俊彦　
  重症筋無力症患者の末梢T 細胞サブセットに免疫抑制薬物療法が及ぼす影響と治療応答性との関連

第7 回　日本消化管学会

2011 年2 月　於　京都
恩田　健二，澁谷　陽子，平野　俊彦
  胃組織におけるヘムオキシゲナーゼ系と血管内皮増殖因子

日本薬学会　第131 年会

2011 年3 月　於　静岡
里村　藍子，清海　杏奈，蒔田益次郎，平野　俊彦
  3次元培養ヒト乳癌組織から分泌される免疫機能に影響を及ぼすサイトカインの研究

高木　美和，増田　眞之，前野　朱美，田中　祥子，井戸　信博，伊藤　　傑，内海　裕也，平野　俊彦
  重症筋無力症患者における自己抗体産生に末梢制御性T 細胞が及ぼす影響

講演会等発表記録
第83 回　東京医科大学・東京薬科大学・免疫アレルギー研究会

2010 年6 月　於　東京
高木　美和，増田　眞之，田中　祥子，森崎　裕哉，松本　　萌，田中千菜美，井戸　信博，大塚　敬男，西田　昌史，伊藤　　操，明石　貴雄，内海　裕也，平野　俊彦
  重症筋無力症患者末梢リンパ球における共刺激分子発現に免疫抑制薬物療法が及ぼす影響

第84 回　東京医科大学・東京薬科大学・免疫アレルギー研究会

2010 年11月　於　東京
下平　智秀，田中　祥子，高坂　　聡，明石　真和，吉川　憲子，中林　　巌，吉田　雅治，白井小百合，明石　貴雄，平野　俊彦
  微小変化型ネフローゼ症候群患者末梢血単核細胞における免疫抑制薬感受性と治療応答性との関連