Azumi M, Kusama K, Yoshie M, Nakano S, Tsuru A, Kato T, Tamura K.
Involvement of ferroptosis in eribulin-induced cytotoxicity in ovarian clear cell carcinoma.
Eur J Pharmacol. 27:176544 (2024) PMID:38552939

Yoshida K, Kusama K, Shinohara G, Sato S, Yoshie M, Tamura K.
Quercetin stimulates trophoblast fusion via the mitochondrial function.
Sci Rep. 14:287 (2024) PMID:38168580

Sakurai T, Kusama K, Imakawa K.
Progressive Exaptation of Endogenous Retroviruses in Placental Evolution in Cattle.
Biomolecules 13:1680 (2023) PMID:38136553 Review

Tsuru A, Yoshie M, Suzuki M, Mochizuki H, Kametaka S, Ohmaru-Nakanishi T, Azumi M, Kusama K, Kato K, Tamura K.
Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.
J Endocrinol 260:e230163 (2023) PMID:37965940

Tsuru A, Yoshie M, Negishi R, Mukoyama T, Yonekawa R, Kojima J, Azumi M, Kusama K, Nishi H, Tamura K.
Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells.
J Pharmacol Sci 153:188-196 (2023) PMID:37973216

Yoshie M, Ohishi K, Ishikawa G, Tsuru A, Kusama K, Azumi M, Tamura K.
Small GTP-binding protein Rap1 mediates EGF and HB-EGF signaling and modulates EGF receptor expression in HTR-8/SVneo extravillous trophoblast cells.
Reprod Med Biol 22:e12537 (2023) PMID:37614815

Nakamura K, Kusama K, Hori M, Imakawa K.
Global analyses and potential effects of extracellular vesicles on the establishment of conceptus implantation during the peri-implantation period.
J Reprod Dev 69:246-253 (2023) PMID:37495510

田村和広、久慈直昭「不妊症に対する先進医療: 子宮内環境検査」ファルマシア（日本薬学会）Vol.60 No.3 ppt.203-208 (2024) 総説

吉江幹浩「胎盤形成における短鎖脂肪酸の役割〜栄養膜細胞の分化・融合に対する短鎖脂肪酸の効果〜」細胞 vol.56 No.3 ppt.65-67 (2024) 著書

草間和哉「新規ゲノム内在性因子による妊娠高血圧症候群の病態解明への挑戦」細胞 vol.56 No.3 ppt.54-56 (2024) 著書

今川和彦、草間和哉「アミノ酸プロファイルによる不受胎牛の判別（利用可能性と今後について）」畜産技術 Vol. 815 4月 (2023) 著書

Bai R, Kusama K, Matsuno Y, Bai H,  Sakurai T, Kimura K, Imakawa K.
Expression of NFIL3 and CEBPA regulated by IFNT induced-PGE2 in bovine endometrial stromal cells during the pre-implantation period.
Front Endocrinol 14:1075030 (2023) PMID:36923228

Yoshida K, Kusama K, Azumi M, Yoshie M, Kato K, Tamura K.
Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts.
J Pharmacol Sci 150:267-274 (2022) PMID:36344049

Azumi M, Yoshie M, Nakachi N, Tsuru A, Kusama K, Tamura K.
Stathmin expression alters the antiproliferative effect of eribulin in leiomyosarcoma cells.
J Pharmacol Sci 150:259-266 (2022) PMID:36344048

Kusama K, Suzuki T, Motohashi R, Nobusawa T, Ota K, Azumi M, Yoshie M, Miyaoka H, Tamura K.
Cordyceps militaris Extract and the Main Component, Cordycepin, Modulate the Functions of Prostate Cancer Cells Partially through the Adenosine A1 Receptor.
Nat Prod Commun 17:1-6 (2022) PMID:

Azumi M, Yoshie M, Takano W, Ishida A, Kusama K, Tamura K.
The impact of eribulin on stathmin dynamics and paclitaxel sensitivity in ovarian cancer cells.
Biol Pharm Bull 45:1627-1635 (2022) PMID:36328498

Kusama K, Satoyoshi A, Azumi M, Yoshie M, Kojima J, Mizuno Y, Ono M, Nishi H, Kajihara T, Tamura K.
Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells.
Front Endocrinol 13:966455 (2022) PMID:36093086

Imakawa K, Kusama K, Kaneko-Ishino T, Nakagawa S, Kitao K, Miyazawa T, Ishino F.
Endogenous Retroviruses and Placental Evolution, Development, and Diversity.
Cells 11:2458 (2022) PMID: 35954303 Review

Plianchaisuk A, Kusama K, Kato K, Sriswasdi S, Tamura K, Iwasaki W.
Origination of LTR retroelement-derived NYNRIN coincides with therian placental emergence.
Mol Biol Evol. 39:msac176 (2022) PMID:35959649

Tsuru A, Yoshie M, Kojima J, Yonekawa R, Azumi M, Kusama K, Nishi H, Tamura K.
PGRMC1 regulates cellular senescence via modulating FOXO1 expression in decidualizing endometrial stromal cells.
Biomolecules 12:1046 (2022) PMID:36008941

Rashid MB, Marey MA, Fukuda K, Haneda S, Kusama K,  Shimada M, Imakawa K, Miyamoto A.
Intrauterine infusion of low levels of interferon-tau on day-8 post-estrus stimulates the bovine endometrium to secrete apolipoprotein-A1: A possible implication for early embryo tolerance.
Am J Reprod Immunol 4:e13592 (2022) PMID:35785505

Tsuru A, Yoshie M, Yonekawa R, Kojima J, Azumi M, Kusama K, Nishi H, Tamura K.
Possible Involvement of miR-98 in the Regulation of PGRMC1 During Decidualization.
Reprod Med 3:189-200 (2022) PMID:

今川和彦、草間和哉「アミノ酸プロファイルによる不受胎牛の判別ー利点と欠点ー」臨床獣医 Vol. 41 No.2 ppt.25-29 (2023) 著書

田村和広、草間和哉「セノリティック制御にもとづく新規子宮内膜症治療薬は可能か？」細胞 vol.55 No.2 ppt.36-38 (2023) 著書

Kusama K, Bai R, Matsuno Y, Ideta A, Sakurai T, Nagaoka K, Hori M,  Imakawa K.
Characterization of serum metabolome and proteome profiles identifies SNX5 specific for pregnancy failure in Holstein heifers.
Life 12:309 (2022) PMID:35207596

Yoshida K, Yano A, Kusama K, Ishikawa G, Tamura K.
Alpha 1 antitrypsin regulates trophoblast syncytialization and inflammatory factor expression.
Int J Mol Sci 23:1955 (2022) PMID:35216073

Matsuno Y, Kusama K, Imakawa K.
Characterization of lncRNA functioning in ovine conceptuses and endometria during the peri-implantation period.
Biochem Biophys Res Commun 594:22-30 (2022) PMID: 35066376

Yoshie M, Kusama K, Tanaka R, Okubo T, Kojima J, Takaesu Y, Isaka K, Nishi H, Tamura K.
Possible roles of calreticulin in uterine decidualization and receptivity in rats and human.
Int J Mol Sci 22:10505 (2021) PMID: 34638846

Kusama K, Fukushima Y, Yoshida K, Azumi M, Yoshie M, Mizuno Y, Kajihara T, Tamura K.
PGE2 and thrombin induce myofibroblast transdifferentiation via activinA and CTGF in endometrial stromal cells.
Endocrinology 162: bqab207 (2021) PMID: 34606582

Nakamura K, Kusama K, Hori M, Imakawa K.
The effect of bta-miR-26b in intrauterine extracellular vesicles on maternal immune system during the implantation period.
Biochem Biophys Res Commun 573:100-106 (2021) PMID: 34403805

Kusama K, Yamauchi N, Yoshida K, Azumi M, Yoshie M, Tamura K.
Senolytic treatment modulates decidualization in human endometrial stromal cells.
Biochem Biophys Res Commun 571:174-180 (2021) PMID: 34330061

Murata H, Kunii H, Kusama K, Sakurai T, Bai H, Kawahara M, Takahashi M.
Heat stress induces oxidative stress and activates the KEAP1-NRF2-ARE pathway in bovine endometrial epithelial cells.
Biol Reprod 105:1114-1125 (2021) PMID: 34296252

Kusama K, Rashid MB, Kowsar R, Marey MA, Talukder AK, Nagaoka K, Shimada M, Khatib H, Imakawa K, Miyamoto A.
Day 7 embryos change the proteomics and exosomal micro-RNAs content of bovine uterine fluid: Involvement of innate immune functions.
Front Genet 12:676791 (2021) PMID: 34262596

Kusama K, Fukushima Y, Yoshida K, Sakakibara H, Tsubata N, Yoshie M, Kojima J, Nishi H, Tamura K.
Endometrial epithelial-mesenchymal transition (EMT) by menstruation-related inflammatory factors during hypoxia.
Mol Hum Reprod 27:gaab036 (2021) PMID: 33983443

Yoshie M, Ishida A, Ohhashi H, Nakachi N, Azumi M, Tamura K.
Stathmin dynamics modulate the activity of eribulin in breast cancer cells.
Pharmacol Res Perspect  9:e00786 (2021) PMID: 34176226

Matsuno Y, Amin YA, Kusama K, Imakawa K.
Formation of fibrin at sights of conceptus adhesion in the ewe.
Reproduction 161:1-12 (2021) PMID: 33852426

Yoshida K, Kusama K, Fukushima Y, Ohmaru-Nakanishi T, Kato K, Tamura K.
Alpha-1 antitrypsin-induced endoplasmic reticulum stress promotes invasion by extravillous trophoblasts.
Int J Mol Sci 22:3683 (2021) PMID: 33916165

吉江幹浩、津留涼也、小島淳哉、草間和哉、西洋孝、田村和広
子宮内膜間質細胞の脱落膜化過程における細胞老化とプロゲステロン受容体膜構成因子1との関係
日本生殖内分泌学会雑誌　2021年26巻 pp.24-29.

Fiorenza MF, Marey M, Rashid MB, Zinnah MA, Ma D, Morillo VA, Kusama K, Shimada M, Imakawa K, Antoniazzi AQ, Miyamoto A.
Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy.
Biochem Biophys Res Commun 553:37-43 (2021) PMID: 33765557

Ando Y, Kuroda A, Kusama K, Matsutani T, Matsuda A, Tamura K.
Impact of serine protease inhibitor alpha1-antitrypsin on expression of endoplasmic reticulum stress-induced proinflammatory factors in adipocytes. 
Biochem Biophys Rep, 26:100967 (2021) PMID: 33732904

Ohnuki N, Kobayashi T, Matsuo M, Nishikaku K, Kusama K, Torii Y, Inagaki Y, Hori M, Imakawa K, Satou Y.
A target enrichment high through-put sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP. 
Sci Rep, 11:4521 (2021) PMID: 33633166

Kusama K, Miyagawa M, Ota K, Kuwabara N, Saeki K, Ohnishi Y, Kumaki Y, Aizawa T, Nakasone T, Okamatsu S, Miyaoka H, Tamura K.
Cordyceps Militaris fruit body extract decreases testosterone catabolism and testosterone-stimulated prostate hypertrophy.
Nutrients,13:50 (2021) PMID:33375244

Inagaki Y, Kobayashi T, Suda Y, Kusama K, Imakawa K.
Genetic variation in Japanese Holstein cattle for EBL development.
BMC Vet Res, 16:407 (2020) PMID: 33115449

Nakamura K, Kusama K, Suda Y, Fujiwara H, Hori M, Imakawa K.
Emerging Role of Extracellular Vesicles in Embryo–Maternal Communication throughout Implantation Processes.
Int J Mol Sci, 21:E5523 (2020) PMID:32752293  Review

中村圭吾、草間和哉、須田義人、堀正敏、今川和彦
反芻動物の着床期における細胞外分泌小胞エクソソームの役割と展望
日本畜産学会報, 92 (2): 131-139 (2021) Review

田村和広（監修）
薬がみえる Vol.4 「薬理学総論」「薬の作用様式」
メディック・メディア、pp. 2-3; 4-14　著書

田村和広、福本誠二、佐藤文俊
臨床薬学テキストシリーズ [薬理・病態・薬物治療]「第4章 内分泌疾患:  3. 副甲状腺機能亢進症・低下症, 4. 副腎疾患」
中山書店、pp. 333 – 357　著書

田村和広、吉江幹浩、船田正彦、鈴木勉、草間和哉、宮岡宏明
最新 薬理学要説（田村和広 編）
愛智出版　著書

Talukde AK, Marey MA, Shirasuna K, Kusama K, Shimada M, Imakawa K, Miyamoto A.
Roadmap to pregnancy in the first 7 days post-insemination in the cow: Immune crosstalk in the corpus luteum, oviduct, and uterus
Theriogenology, 150:313-320 (2020) PMID:32088048 Review

Nakamura K, Kusama K, Ideta A, Imakawa K, Hori M.
IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle
Reproduction, 159:503-511 (2020) PMID:32103820

Nakamura K, Kusama K, Ideta A, Kimura K, Hori M, Imakawa K.
Effects of miR-98 in intrauterine extracellular vesicles on maternal immune regulation during the peri-implantation period in cattle
Sci Rep, 9:20330 (2019) PMID:31889113

吉江幹浩
基礎と臨床からみた胎盤学「脱落膜の機能 脱落膜(細胞)の役割」
メディカルレビュー社（日本胎盤学会編）　著書

吉江幹浩「1章 薬理学の基礎」
田村和広「6章 感覚器系薬理(眼/皮膚作用薬), ７章 内分泌系薬理 (副腎,性腺系)」
薬系薬理学書（立川・田野中・弘瀬 編）（南江堂）  著書

Kusama K, Tamura K, Bai H, Sakurai T, Nishi H, Isaka K, Imakawa K, Yoshie M.
Exchange protein directly activated by cAMP (EPAC) promotes transcriptional activation of the decidual prolactin gene via CCAAT/enhancer-binding protein in human endometrial stromal cells
Reprod Fertil Dev, 30:1454-1461 (2018) PMID:29735004

Tamura K, Ishikawa G, Yoshie M, Ohneda W, Nakai A, Takeshita T, Tachikawa E.
Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts
J Pharmacol Sci, 135:89-95. (2017) PMID:29056256

Matsutani T, Tamura K, Kutsukake M, Matsuda A, Tachikawa E, Uchida E.
Impact of Pioglitazone on Macrophage Dynamics in Adipose Tissues of Cecal Ligation and Puncture-Treated Mice
Biol Pharm Bull, 40:638-644 (2017) PMID: 28458349

Tamura K, Naraba H, Hara T, Nakamura K, Yoshie M, Kogo H, Tachikawa E.
Positive Feedback Loop between Progesterone and Microsomal Prostaglandin E Synthase-1-mediated PGE2 Promotes Production of Both in Mouse Granulosa Cells
Prostaglandins Other Lipid Mediat, 123:56-62 (2016) PMID:27174800

Wongwananuruk T, Sato T, Kajihara T, Matsumoto S, Akita M, Tamura K, Brosens JJ, Ishihara O.
Endometrial Androgen Signaling and Decidualization Regulate Trophoblast Expansion and Invasion in Co-culture: A Time-lapse Study
Placenta, 47:56-62 (2016) PMID:27780540

Kusama K, Yoshie M, Tamura K, Imakawa K, Isaka K, Tachikawa E.
Regulatory Action of Calcium Ion on Cyclic AMP-Enhanced Expression of Implantation-Related Factors in Human Endometrial Cells
PLoS One, 10:e0132017 (2015) PMID:26161798

Yoshie M, Kusama K, Tamura K.
Molecular mechanisms of human endometrial decidualization through cyclic adenosine monophosphate signaling pathways
Journal of mammalian ova research, 32:95-102 (2015) https://doi.org/10.1274/jmor.32.95 Review

吉江幹浩、草間和哉、田村和広、山崎梨沙香、立川英一
ラット子宮間質細胞の脱落膜化におけるCalreticulinの役割
日本生殖内分泌学会雑誌（研究フロンティア）2015年 20巻 pp.35-40. Review

田村和広（監修）
薬がみえる Vol.2 「内分泌系の疾患と薬：副腎、性ホルモン」
メディックメディア　著書

Tamura K, Takashima H,Fumoto K, Kajihara K, Uchino S, Ishihara O, Yoshie M, Kusama K, Tachikawa E.
Possible role of α₁-antitrypsin in endometriosis-like grafts from a mouse model of endometriosis
Reprod Sci, 22:1088-1097 (2015) PMID:25667209

Kusama K, Yoshie M, Tamura K, Imakawa K, Tachikawa E.
EPAC2-mediated calreticulin regulates LIF and COX2 expression in human endometrial glandular cells
J Mol Endocrinol, 54:17-24 (2015) PMID:25378661

Kutsukake M, Matsutani T, Tamura K,  Matsud A, Kobayashi M, Tachikawa E, Uchida E.
Pioglitazone attenuates lung injury by modulating adipose inflammation
J Surg Res, 189:295-303 (2014) PMID:24713471

Tamura K, Yoshie M, Hashimoto K, Tachikawa E.
Inhibitory effect of insulin-like growth factor-binding protein-7 (IGFBP7) on in vitro angiogenesis of vascular endothelial cells in rat corpus luteum
J Reprod Dev, 60:447-453 (2014) PMID:25212428

Daikoku T, Terakawa J, Hossain MM, Yoshie M,  Cappelletti M, Yang P, Ellenson LH, Dey SK.
Mammalian target of rapamycin complex 1 and cyclooxygenase 2 pathways cooperatively exacerbate endometrial cancer
Am J Pathol, 184:2390-2402 (2014) PMID:25058027

Kusama K, Yoshie M, Tamura K, Daikoku T, Takarada T, Tachikawa E.
Possible roles of the cAMP-mediators EPAC and RAP1 in decidualization of rat uterus
Reproduction, 147:897-906 (2014) PMID:24586073

Hasegawa E, Nakagawa S, Miyate Y, Takahashi K, Ohta S, Tachikawa E, Yamato S.
Inhibitory Effect of Protopanaxatriol Ginseng Metabolite M4 on the Production of Corticosteroids in ACTH-stimulated Bovine Adrenal Fasciculata Cells
Life Sci, 92, 687-693 (2013) PMID:23376775

Tamura K, Yoshie M, Miyajima E, Kano M, Tachikawa E.
Stathmin Regulates Hypoxia-Inducible Factor-1α Expression through the Mammalian Target of Rapamycin Pathway in Ovarian Clear Cell Adenocarcinoma
ISRN Pharmacol, 2013:279593 (2013) PMID:23819061

Daikoku T, Yoshie M, Xie H, Sun X, Cha J, Ellenson LH, Dey SK.
Conditional Deletion of Tsc1 in the Female Reproductive Tract Impedes Normal Oviductal and Uterine Function by Enhancing mTORC1 Signaling in Mice
Mol Hum Reprod, 19:463-472 (2013) PMID:23475984

Gu HF, Gu T, Hilding A, Zhu Y, Kärvestedt L, Östenson CG, Lai M, Kutsukake M, Frystyk J, Tamura K, Brismar K.
Evaluation of IGFBP-7 DNA Methylation Changes and Serum Protein Variation in Swedish Subjects with and without Type 2 Diabetes
Clin Epigenetics, 5:20 (2013) PMID:24180466

Kusama K, Yoshie M, Tamura K, Nakayama T, Nishi H, Isaka K, Tachikawa E.
The Role of Exchange Protein Directly Activated by Cyclic AMP 2-mediated Calreticulin Expression in the Decidualization of Human Endometrial Stromal Cells
Endocrinology, 155:240-248 (2014) PMID:24169561

田村 和広，吉江 幹浩
産婦人科の実際，胎盤 -生理から病態へ-　絨毛細胞の分化機序
金原出版　62，1033－1039，2013 Review

田村 和広
基礎から学ぶ　内分泌薬学　”性ホルモン”　厚味 厳一 編
エルゼビア・ジャパン　121－156，2013　著書

Shinohara A, Kutsukake M, Takahashi M, Kyo S, Tachikawa E, Tamura K.
Protease-activated receptor-stimulated interleukin-6 expression in endometriosis-like lesions in an experimental mouse model of endometriosis
J Pharmacol Sci, 119:40-51 (2012) PMID:22641126

Burnum KE, Hirota Y, Baker ES, Yoshie M, Ibrahim YM, Monroe ME, Anderson GA, Smith RD, Daikoku T, Dey SK.
Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua
Endocrinology, 153:4568-4579 (2012) PMID:22759378

Hasegawa E, Nakagawa S, Sato M, Tachikawa E, Yamato S.
Effect of Polyphenols on Production of Steroid Hormones from Human Adrenocortical NCI-H295R Cells
Biol Pharm Bull, 36:228-237 (2013) PMID:23370353

Kusama K, Yoshie M, Tamura K, Kodaka Y, Hirata A, Sakurai T, Bai H, Imakawa K, Nishi H, Isaka K, Nagai T, Nagao T, Tachikawa E.
Regulation of decidualization in human endometrial stromal cells through exchange protein directly activated by cyclic AMP (Epac)
Placenta, 34:212-221 (2013)  PMID:23352189

Sakurai T, Suzuki K, Yoshie M, Hashimoto K, Tachikawa E, Tamura K.
Stimulation of Tube Formation Mediated Through the Prostaglandin EP2 Receptor in Rat Luteal Endothelial Cells
J Endocrinol, 209:33-43 (2011) PMID:21273371

Tsujimura Y, Matsutani T, Matsuda A, Kutsukake M, Uchida E, Sasajima K, Tamura K.
Effects of Pioglitazone on Survival and Omental Adipocyte Function in Mice with Sepsis Induced by Cecal Ligation and Puncture
J Surg Res, 171:e215-221 (2011) PMID:21962804

Hirota Y, Cha J, Yoshie M, Daikoku T, Dey SK.
Heightened Uterine Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling Provokes Preterm Birth in Mice
Proc Natl Acad Sci U S A, 108:18073-18078 (2011) PMID:22025690

Nishioka H, Tamura K, Iida H, Kutsukake M, Endo A, Ikeda Y, Haraoka J.
Co-expression of Somatostatin Receptor Subtypes and Estrogen Receptor-α mRNAs by Non-functioning Pituitary Adenomas in Young Patients
Mol Cell Endocrinol, 331:73-78（2011）PMID:20797424

Yamato S, Nakagawa S, Yamazaki N, Aketo T, Tachikawa E.
Simultaneous Determination of Pregnenolone and 17α-Hydroxypregnenolone by Semi-micro High-erformance Liquid Chromatography with an Immobilized Cholesterol Oxidase as a Pre-column Reactor: Application to Bovine Adrenal Fasciculata Cells
J Chromatogr B Analyt Technol Biomed Life Sci, 878:3358-3362（2010）PMID:21081289

Yoshie M, Kaneyama K, Kusama K, Higuma C, Nishi H, Isaka K, Tamura K.
Possible Role of the Exchange Protein Directly Activated by Cyclic AMP (Epac) in the Cyclic AMP-dependent Functional Differentiation and Syncytialization of Human Placental BeWo Cells 
Hum Reprod, 25:2229-2238（2010）PMID:20663796

Ohbayashi K, Tanaka K, Kitajima K, Tamura K, Hara T.
Novel Role for the Intraflagellar Transport Protein CMG-1 in Regulating the Transcription of Cyclin-D2, E-cadherin and Integrin-α Family Genes in Mouse Spermatocyte-derived Cells
Genes Cells, 15:699-710（2010）PMID:20545763