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原著論文・総説
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2023年4月〜
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1. De, K., Hirooka, T., Sasaki, Y., Yasutake, A., Hara, T., *Yamamoto, C., Fujiwara, Y., Shinoda, Y., Fujie, T., Katsuda, S., Eto, K., *Kaji, T. Pathogenesis of selective damage of granule cell layer in cerebellum of rats exposed to methylmercury. J. Toxicol. Sci., 48(7), 429-439, 2023. https://doi.org/10.2131/jts.48.429 ２ Tokumoto, M., Lee, J.Y., Fujiwara, Y., *Satoh, M. Long-term exposure to cadmium causes hepatic iron deficiency through the suppression of iron-transport-related gene expression in the proximal duodenum. Toxics, 11(7), 641, 2023. https://doi.org/10.3390/toxics11070641 ３． 【Review】*Shinoda Y., Akiyama M., Toyama T. Potential association between methylmercury neurotoxicity and inflammation. Biol. Pharm. Bull., 46(9), 1162-1168, 2023. https://doi.org/10.1248/bpb.b23-00075 ４． *Hara, T., Kumagai, R., Tanaka, T., Nakano, T., Fujie, T., Fujiwara, Y., *Yamamoto, C., *Kaji, T. Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI2 pathway in cultured bovine vascular endothelial cell. J. Toxicol. Sci., 48(12), 655-663, 2023. https://doi.org/10.2131/jts.48.655 |
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2022年4月〜
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１. Katsuzawa, T., Kujirai, K., Kamisuki, S., *Shinoda, Y. Avenaciolide Induces Apoptosis in Human malignant meningioma cells through the production of reactive oxygen species. Biol. Pharm. Bull., 45(4), 517-521. https://doi.org/10.1248/bpb.b21-01039 ２． Sato, Y., Tsuyusaki, M., Takahashi-Iwanaga, H., Fujisawa, R., Masamune, A., Hamada, S., Matsumoto, R., Tanaka, Y., Kakuta, Y., Yamaguchi-Kabata, Y., Furuse, T., Wakana, S., Shimura, T., Kobayashi, R., Shinoda, Y., Goitsuka, R., Maezawa, S., Sadakata, T., Sano, Y., *Furuichi, T. Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice. Front. Mol. Biosci., 9, 1040237, 2022. 10.3389/fmolb.2022.1040237. ３． Hara, T., Konishi, T., Yasuike, S., Fujiwara, Y., Yamamoto, C., *Kaji, T. Sb-Phenyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine induces perlecan core protein synthesis in cultured vascular endothelial cells. Int. J. Mol. Sci., 24(4), 3656, 2023. https://doi.org/10.3390/ijms24043656 |
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2021年4月〜
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Li J., Shinoda Y., Ogawa S., IkegayaS., Li S., Matsuyama Y., Sato K., *Yamagishi S. Expression of FLRT2 in postnatal central nervous system development and after spinal cord injury. Front. Mol. Neurosci., 14, 756264, 2021. https://doi.org/10.3389/fnmol.2021.756264 ８． *Furuichi, T., Muto, Y., Sadakata, T., Sato, Y., Hayashi, K., Shiraishi-Yamaguchi, Y., *Shinoda, Y. The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells. Mol. Brain, 14, 90, 2021. https://doi.org/10.1186/s13041-021-00804-8 7. *Wada, M., Takano, K., Ide, M., Sano, Y., Shinoda, Y., Furuichi, T., Kansaku, K. Task-related c-Fos expression in the posterior parietal cortex during the “rubber tail task” is diminished in Ca2+-dependent activator protein for secretion 2 (Caps2)-knockout mice. Front. in Behav. Neurosci., 15, 680206, 2021. https://doi.org/10.3389/fnbeh.2021.680206 6. *Tsuneoka, Y., Nishimura, T., Oka, J. Fluorescein permeability of the blood-brain barrier is enhanced in juvenile- but not young adult-onset type 1 diabetes in rats. Biol. Pharm. Bull., 44(8), 1088-1092, 2021. https://doi.org/10.1248/bpb.b21-00248 5. Fujima, S., Yamaga, R., Minami, H., Mizuno, S., Shinoda, Y., Sadakata, T., Abe, M., Sakimura, K., Sano, Y., *Furuichi, T. CAPS2 deficiency impairs the release of the social peptide, oxytocin, as well as oxytocin-associated social behavior. J. Neurosci., 41(20), 4524-4535, 2021. https://doi.org/10.1523/jneurosci.3240-20.2021 ４． Ishii, C., Shibano, N., Yamazaki, M., Arima, T, Kato, Y., Ishii, Y., Shinoda, Y., Sadakata, T., Sano, Y., *Furuichi, T. CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning. Sci. Rep., 11, 8656, 2021. https://doi.org/10.1038/s41598-021-88009-w ３. *Shinoda, Y., Yamada, Y., Yoshida, E., Takahashi, T., Tsuneoka, Y., Eto, K., *Kaji, T., *Fujiwara Y. Hypoalgesia and recovery in methylmercury-exposed rats. J. Toxicol. Sci., 46(6), 303-309, 2021. https://doi.org/10.2131/jts.46.303 2. Nakano, T., Takahashi, T., Yamamoto, C., *Kaji, T., *Fujiwara, Y. Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells. J. Toxicol. Sci., 46(4), 187-192, 2021. https://doi.org/10.2131/jts.46.187 1. Toyama, T., Wang, Y., Kim, M.S., Takahashi, T., Naganuma, A., *Hwang, G.W. Increased expression of TCF3, transcription factor 3, is a defense response against methylmercury toxicity in mouse neuronal C17.2 cells. Toxicol. Res., 37, 451-458, 2021. https://doi.org/10.1007/s43188-021-00087-0 |
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2020年4月〜2021年3月
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15. Sugimoto H., Horii T., Hirota J., Sano Y., Shinoda Y., Konno A., Hirai H., Ishizaki Y., Hirase H., Hatada I., Furuichi T., *Sadakata T. The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice. Mol. Brain, 14, 52, 2021. 10.1186/s13041-021-00766-x 14． *Shinoda, Y., Kato, D., Ando, R., Endo, H., Takahashi, T., Tsuneoka, Y., *Fujiwara, Y. Systematic review and meta-analysis of in vitro anti-human cancer experiments investigating the use of 5-aminolevulinic acid (5-ALA) for photodynamic therapy. Pharmaceuticals, 14(3), 229,2021. https://doi.org/10.3390/ph14030229 13. 【総説】*佐藤雅彦, 李辰竜, 徳本真紀, 本田晶子, 藤原泰之．カドミウム毒性発現分子機構とその防御. 愛知学院大学薬学会誌, 13, 1-10, 2020. 12. Nakano T., Takahashi T., Yamamoto C., Yoshida E., *Kaji T., *Fujiwara Y. Arsenite inhibits tissue-type plasminogen activator synthesis through NRF2 activation in cultured human vascular endothelial EA.hy926 cells. Int. J. Mol. Sci., 22(2), 739, 2021. 11. Nakamura, T., Yoshida, E., Hara, T., Fujie, T., Yamamoto, C., Fujiwara, Y., Ogata, F., Kawasaki, N., Takita, R., *Uchiyama, M., *Kaji, T. Zn(II)2,9-dimethyl- 1,10-phenanthroline stimulates cultured bovine aortic endothelial cell proliferation. RSC Adv., 10(69), 42327-42337, 2020. 10. #Fujie T., #Ozaki Y., #Takenaka F., Nishio M., Hara T., Fujiwara Y., *Yamamoto C., *Kaji T. Induction of metallothionein isoforms in cultured bovine aortic endothelial cells exposed to cadmium. J. Toxicol. Sci., 45(12), 801-806, 2020. #These authors equally contributed to this work. 9. *Shinoda Y., Kujirai K., Aoki K., Morita M., Masuda M., Zhang L., Kaixin Z., Nomoto A., Takahashi T., Tsuneoka Y., Akimoto J., Kataoka H., Rachi R., Narumi A., Yoshimura T., Yano S., *Fujiwara Y. Novel photosensitizer β-mannose-conjugated chlorin e6 as a potent anticancer agent for human glioblastoma U251 cells. Pharmaceuticals, 13(10), 316, 2020. 8. *Yoshizawa K., Nakashima K., Tabuchi M., Okumura A., Nakatake Y., Yamada M., Tsuneoka Y., Higashi T. Benzothiazepines, diltiazem and JTV-519, exert an anxiolytic-like effect via neurosteroid biosynthesis in mice. J. Pharmacol. Sci., 143(3), 234-237, 2020. 7. Takahashi T., Misawa S., Suzuki S., Saeki N., Shinoda Y., Tsuneoka Y., Akimoto J., *Fujiwara Y. Possible mechanism of heme oxygenase-1 expression in rat malignant meningioma KMY-J cells subjected to talaporfin sodium-mediated photodynamic therapy. Photodiagnosis Photodyn. Ther., 32, 102009, 2020. 6. Takahashi T., Yumoto A., Miyazaki Y., Shinoda Y., Tsuneoka Y., *Kaji T., *Fujiwara Y. Nucleolin knockdown enhances cadmium cytotoxicity in cultured vascular endothelial cells. BPB Rep., 3(4), 142-145, 2020. 5. Takahashi T., Takagi Y., Honma Y., Shinoda Y., Tsuneoka Y., Hara T., Yamamoto C., *Kaji T., *Fujiwara Y. Nucleolin positively regulates spontaneous cell proliferation but is not involved in inhibition of proliferation by lead in cultured bovine aortic endothelial cells. Fundam. Toxicol. Sci., 7(5), 233-239, 2020. 4. Fujiwara Y., Lee J.Y., Banno H., Imai S., Tokumoto M., Hasegawa T., Seko Y., *Satoh M. Cadmium induces iron deficiency anemia through the suppression of iron transport in the duodenum. Toxicol. Lett., 332, 130-139, 2020. 3. *Shinoda Y., Aoki K., Shinkai A., Seki K., Takahashi T., Tsuneoka Y., Akimoto J., *Fujiwara Y. Synergistic effect of dichloroacetate on talaporfin sodium-based photodynamic therapy on U251 human astrocytoma cells. Photodiagnosis Photodyn. Ther., 31, 101850, 2020. 2. Matsumura M., Takahashi T., Yamauchi H., Sakuma S., Hayashi Y., Hyodo T., Obata T., Yamaguchi K., *Fujiwara Y., *Yasuike, S. Synthesis and anticancer activity of bis(2-arylimidazo[1,2-a]pyridin-3-yl) selenides and diselenides: the copper-catalyzed tandem C―H selenation of 2-arylimidazo[1,2-a]pyridine with selenium. Beilstein J. Org. Chem., 16, 1075-1083, 2020. 1. #Takahashi T., #Nakano T., Katoh G., Shinoda Y., Yamamoto C., Yoshida E., *Kaji T., *Fujiwara Y. Nuclear factor erythroid 2-related factor 2 (NRF2) is a negative regulator of tissue plasminogen activator synthesis in cultured human vascular endothelial EA.hy926 cells. J. Toxicol Sci., 45(4), 237-243, 2020. #These authors equally contributed to this work. |
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2019年4月〜2020年3月
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1. #Fujie T., #Takenaka F., Yoshida E., Yasuike S., Fujiwara Y., Shinkai Y., Kumagai Y., Yamamoto C., *Kaji T. Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells. J. Toxicol. Sci., 44(5), 327-333, 2019. #These authors equally contributed to this work. 2. *Wada M., Ide M., Atsumi T., Sano Y., Shinoda Y., Furuichi T., Kansaku K. Rubber tail illusion is weakened in Ca2+-dependent activator protein for secretion 2 (Caps2)-knockout mice. Sci. Rep., 9, 7552, 2019. 3. *Shinoda Y., Tatsumi S., Yoshida E., Takahashi T., Eto K., *Kaji T., *Fujiwara Y. Gene expression profiles in the dorsal root ganglia of methylmercury-exposed rats. J. Toxicol Sci., 44(8), 549-558, 2019. 4. Hosoi N., Shibasaki K., Hosono M., Konno A., Shinoda Y., Kiyonari H., Inoue K., Muramatsu S., Ishizaki Y., Hirai H., Furuichi T., *Sadakata T. Deletion of class II ARFs in mice causes tremor by the Nav1.6 loss in cerebellar Purkinje cell axon initial segments. J. Neurosci., 39(32), 6339-6353, 2019. 5. #Takahashi T., #Kim M.S., Iwai-Shimada M., Hoshi T., Fujimura M., Toyama T., Fujiwara Y., Naganuma A., *Hwang G.W. Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells. Environ. Toxicol. Pharmacol., 71, 103216, 2019. #These authors equally contributed to this work. 6. Namekata I., Tanaka Y., Ohmori T., Tsuneoka Y., Hamaguchi S., *Tanaka H. Cell morphology and early-phase Ca2+ transients of Guinea-pig pulmonary vein cardiomyocytes compared with atrial and ventricular cardiomyocytes. bioimages, 27, 1-12, 2019. 7. Hara T., Wakata T., Fujiwara Y., Yamamoto C., *Kaji T. Induction of versican V0 variant synthesis by a thrombin receptor agonist peptide in cultured human coronary smooth muscle cells. BPB Rep., 2(6), 106-112, 2019. 8. Toyama T., Xu S., Nakano R., Hasegawa T., Endo N., Takahashi T., Lee J.Y., Naganuma A., *Hwang G.W. The nuclear protein HOXB13 enhances methylmercury toxicity by inducing oncostatin M and promoting its binding to TNFR3 in cultured cells. Cells, 9(1), 45, 2020. 9 #Wu D.P., #Nakano T., Tsuneoka Y., Takahashi T., Shinoda Y., *Kaji T., *Fujiwara Y. Arsenite inhibits gene expression of perlecan, syndecan-1, -2, -3 and biglycan in cultured vascular endothelial cells. Fundam. Toxicol Sci., 7(2), 77-83, 2020. #These authors equally contributed to this work. |
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2018年4月〜2019年3月
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1. Lee J.Y., Tokumoto M., Hwang G.W., Kim M.S., Takahashi T., Naganuma A. Yoshida M., *Satoh M. Effect of metallothionein-III on mercury-induced chemokine gene expression. Toxics, 6(3), 48, 2018. 2. Takahashi T., Kim M.S., Iwai-Shimada M., Fujimura M., Toyama T., Naganuma A., *Hwang G.W. Chemokine CCL4 induced in mouse brain has a protective role against methylmercury toxicity. Toxics, 6, 36, 2018. 3. Takahashi T., Suzuki S., Misawa S., Akimoto J., Shinoda Y., *Fujiwara Y. Photodynamic therapy using talaporfin sodium induces heme oxygenase-1 expression in rat malignant meningioma KMY-J cells. J. Toxicol. Sci., 43(5), 353-358, 2018.（The Japanese Society of Toxicology, Pfizer Highly Cited Paper Award 2021） 4. *Shinoda Y., Sadakata T., Akagi T., Sakamaki Y., Hashikawa T., Sano Y., *Furuichi T. Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals. Neurosci. Lett., 677, 65-71, 2018. 5. Sato M., Lee J.Y., Kim M.S., Takahashi T., Naganauma A., *Hwang G.W. Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells. Fundam. Toxicol. Sci., 5(2), 71-73, 2018. 6. Ichikawa M., *Akimoto J., Miki Y., Maeda J., Takahashi T., Fujiwara Y., Kohno M. Photodynamic therapy with talaporfin sodium induces dose- and time-dependent apoptotic cell death in human malignant meningioma HKBMM cells. Photodiagnosis Photodyn. Ther., 25, 29-34, 2019. 7. *,#Shinoda Y., #Ehara S., Tatsumi S., Yoshida E., Takahashi T., Eto K., *Kaji T., *Fujiwara Y. Methylmercury-induced neural degeneration in rat dorsal root ganglion is associated with the accumulation of microglia/macrophages and the proliferation of Schwann cells. J. Toxicol. Sci., 44(3), 191-199, 2019. #These authors equally contributed to this work.（The Japanese Society of Toxicology, Tanabe Award 2020） 8. Awasthil A., Ramachandran B., Ahmed S., Benito E., Shinoda Y., Nitzan N., Heukamp A., Rannio S., Martens H., Barth J., Burk K., Wang Y.T., Fischer A., *Dean C. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science, 363 (6422), eaav1483, 2019. 9. *Shinoda Y., Sadakata T., Yagishita K., Kinameri E., Katoh-Semba R., Sano Y., *Furuichi T. Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3. Biochem. Biophys. Res. Commun., 509(2), 429-434, 2019. 10. Koebis M., Urata S., Shinoda Y., Okabe S., Yamasoba T., Nakao K., Aiba A., *Furuichi T. LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing. Mol. Brain, 12, 20, 2019. 11. Kim M.S., Takahashi T., Lee J.Y., Toyama T., Hoshi T., Kuge S., Fujiwara Y., Naganuma A., *Hwang G.W. Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells. Sci. Rep., 9, 4631, 2019. |
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2017年4月〜2018年3月
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1. Hara T., Yoshida E., Shinkai Y., Yamamoto C., Fujiwara Y., Kumagai Y., *Kaji T. Biglycan intensifies ALK5-Smad2/3 signaling by TGF-β1 and downregulates syndecan-4 in cultured vascular endothelial cells. J. Cell. Biochem.,118(5), 1087-1096, 2017. 2. Hara T., Yoshida E., Fujiwara Y., Yamamoto C., *Kaji T. Transforming growth factor-β1 modulates the expression of syndecan-4 in cultured vascular endothelial cells in a biphasic manner. J. Cell. Biochem., 118(8), 2009-2016, 2017. 3. Yagishita K., Suzuki R., Mizuno S., Katoh-Semba R., Sadakata T., Sano Y., *Furuichi T., *Shinoda Y. CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus. Neurosci. Lett., 661, 121-125, 2017. 4. Ihara D., *Fukuchi M., Katakai M., Shinoda Y., Katoh-Semba R., Furuichi T., Ishikawa M., Tabuchi A., Tsuda M. Deltamethrin increases neurite outgrowth in cortical neurons through endogenous BDNF/TrkB pathways. Cell Struct. Funct., 42, 141-148, 2017. 5. Nakayama K., Ohashi R., Shinoda Y., Yamazaki M., Abe M., Fujikawa A., Shigenobu S., Futatsugi A., Noda M., Mikoshiba K., Furuichi T., Sakimura K., *Shiina N. RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation. eLife, 6, e29677, 2017. 6. Yamada M., Takahashi T., Hasegawa M., Matsumura M., Ono K., Fujimoto R., Kitamura Y., Murata Y., Kakusawa N., Tanaka M., *Obata T., *Fujiwara Y., *Yasuike S. Synthesis, antitumor activity, and cytotoxicity of 4-substituted 1-benzyl-5-diphenylstibano-1H-1,2,3-triazoles. Bioorg. Med. Chem. Lett., 28(2), 152-154, 2018. |
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2016年4月〜2017年3月
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1. Fujie T., Murakami M., Yoshida E., Tachinami T., Shinkai Y., Fujiwara Y., Yamamoto C., Kumagai Y., *Naka H., *Kaji T. Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells. J. Biol. Inorg. Chem., 21, 263-273, 2016. 2. *Hwang G.W., Fukumitsu T., Ogiwara Y., Takahashi T., Miura N., Kuge S., Naganuma A. Whi2 enhances methylmercury toxicity in yeast via inhibition of Akr1 palmitoyltransferase activity. Biochim. Biophys. Acta, 1860(6), 1326-1333, 2016. 3. Shinoda Y., Ishii C., Fukazawa Y., Sadakata T., Ishii Y., Sano Y., Iwasato T., Itohara S., *Furuichi T. CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3–CA1 synapses in adult hippocampus. Sci. Rep., 6, 31540, 2016. 4. Fujie T., Murakami M., Yoshida E., Yasuike S., Kimura T., Fujiwara Y., Yamamoto C., *Kaji T. Transcriptional induction of metallothionein by tris(pentafluorophenyl)stibane in cultured bovine aortic endothelial cells. Int. J. Mol. Sci., 17(9), 1381, 2016. 5. *Shinoda Y., Nakajima Y., Iguchi H., Tatsumi S., Kitaoka M., Nakajima M., Takahashi T., Fujiwara Y., Furuichi T. Galacto-N-biose is neuroprotective against glutamate-induced excitotoxicity in vitro. Eur. J. Pharmacol., 791, 711-717, 2016. 6. Yoshikawa F., Sato Y., Tohyama K., Akagi T., Furuse T., Sadakata T., Tanaka M., Shinoda Y., Hashikawa T., Itohara S., Sano Y., Ghandour M.S., Wakana S., *Furuichi T. Mammalian-specific central myelin protein opalin is redundant for normal myelination: structural and behavioral assessments. PLoS ONE, 11(11), e0166732, 2016. 7. Lee J.Y., Tokumoto M., Fujiwara Y., Hwang G.W., Lee M.Y., *Satoh M. Sensitivity of MT-III null mice upon chronic exposure to cadmium. Fundam. Toxicol. Sci., 3(6), 285-289, 2016. 8. Iwai-Shimada M., Takahashi T., Kim M.S., Fujimura M., Ito H., Toyama T., Naganuma A., *Hwang G.W. Methylmercury induces the expression of TNF-α selectively in the brain of mice. Sci. Rep., 6, 38294, 2016. 9. *Fujino T., Yokosuka A., Higurashi H., Yokokawa R., Sakurai R., Harashima W., Miki Y., Fujiwara Y., Mimaki Y., Hayakawa M. AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner. J. Nat. Med., 71, 36-43, 2017. 10. *Shinoda Y., Takahashi T., Akimoto J., Ichikawa M., Yamazaki H., Narumi A., Yano S., *Fujiwara Y. Comparative photodynamic therapy cytotoxicity of mannose-conjugated chlorin and talaporfin sodium in cultured human and rat cells. J. Toxicol. Sci., 42(1), 111-119, 2017. 11. *Sadakata T., Shinoda Y., Ishizaki Y., Furuichi T. Analysis of gene expression in Ca2+-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways. Neurosci. Lett., 639, 88-93, 2017. 12. Hara T., Kojima T., Matsuzaki H., Nakamura T., Yoshida E., Fujiwara Y., Yamamoto C., Saito S., *Kaji T. Induction of syndecan-4 by organic-inorganic hybrid molecules with a 1,10-phenanthroline structure in cultured vascular endothelial cells. Int. J. Mol. Sci., 18(2), 352, 2017. 13. Kim M.S., Takahashi T., Lee J.Y., Miura N., Asanuma M., Hwang G.W., *Naganuma A. Identification of transcription factors activated by methylmercury in mouse brain. Fundam. Toxicol. Sci., 4(1) 37-39, 2017. 14. Takahashi T., Wang Y., Toyama T., Kim M.S., Kuge S., Hwang G.W., *Naganuma A. Small interfering RNA-mediated knockdown of the transcription factor TCF3 enhances sensitivity to methylmercury in mouse neural stem cells. Fundam. Toxicol. Sci., 4(2), 41-43, 2017. 15. Hayashi K., Furuya A., Sakamaki Y., Akagi T., Shinoda Y., Sadakata T., Hashikawa T., Shimizu K., Minami H., Sano Y., Nakayama M., *Furuichi T. The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination. PLoS ONE, 12(3), e0173175, 2017. |
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2015年4月〜2016年3月
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1. Murakami M., Fujie T., Matsumura M., Yoshida E., Yamamoto C., Fujiwara Y., Yasuike S., *Kaji T. Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells. Fundam. Toxicol. Sci. 2(2) 61-66, 2015. 2. Miki Y., Tachibana Y., Ohminato Y., *Fujiwara Y. Nucleolin acts as a scavenger receptor for acetylated low-density lipoprotein on macrophages. Biol. Pharm. Bull., 38(9), 1420-1424, 2015. 3. Miki Y., Akimoto J., Moritake K., Hironaka C., *Fujiwara Y. Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells. Lasers Med. Sci., 30(6), 1739-1745, 2015. 4. Miki Y., Akimoto J., Sato A., *Fujiwara Y. Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death. Fundam. Toxicol. Sci., 2(3), 111-116, 2015. 5. Lee J.Y., Tokumoto M., Fujiwara Y., *Satoh M. Involvement of ubiquitin-coding genes in cadmium-induced protein ubiquitination in human proximal tubular cells. J. Toxicol. Sci., 40(6), 901-908, 2015. 6. Takahashi T., Iwai-Shimada M., Syakushi Y., Kim MS., Hwang GW., Miura N., *Naganuma A. Methylmercury induces expression of interleukin-1β and interleukin-19 in mice brains. Fundam. Toxicol. Sci., 2(6), 239-243, 2015. 7. Takahashi T., Kim MS., Hwang GW., Kuge S., *Naganuma A. Knockdown of Acyl-CoA thioesterase 9 gene expresion by siRNA confers resistance to arsenite in HEK293 cells. Fundam. Toxicol. Sci., 2(6), 245-247, 2015. 8. Fujiwara Y.,Yamamoto C., Yoshida E., Kumagai Y., *Kaji T. Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells. Arch. Toxicol., 90(2), 259-267, 2016. 9. Lee J.Y., Tokumoto M., Hattori Y., Fujiwara Y., Shimada A., *Satoh M. Different regulation of p53 expression by cadmium exposure in kidney, liver, intestine, vasculature, and brain astrocytes. Toxicol. Res., 32(1), 73-80, 2016. 10. Lee J.Y., Ishida Y., Takahashi T., Naganuma A., *Hwang G.W. Transport of pyruvate into mitochondria is involved in methylmercury toxicity. Sci. Rep., 6, 21528, 2016. 11. Lee J.Y., Tokumoto M., Fujiwara Y., Hasegawa T., Seko Y., Shimada A., *Satoh M. Accumulation of p53 via down-regulation of UBE2D family genes in a critical pathway for cadmium-induced renal toxicity. Sci. Rep., 6, 21968, 2016. 12. Fujie T., Segawa Y., Kimura T., Fujiwara Y., Yamamoto C., Satoh M., *Naka H., *Kaji T. Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells. J. Toxicol. Sci., 41(2), 225-232, 2016. |
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2014年4月〜2015年3月
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1. *Miki Y., Dambara H., Tachibana Y., Hirano K., Konishi M., Beppu M. Macrophage recognition of toxic advanced glycosylation end products through the macrophage surface-receptor nucleolin. Biol. Pharm. Bull., 37(4), 588-596, 2014. 2. Tokumoto M., Lee J.Y., Fujiwara Y., *Satoh M. Alteration of DNA binding activity of transcription factors in NRK-52E rat proximal tubular cells treated with cadmium. J. Toxicol. Sci., 39(5), 735-738, 2014. 3. *Miki Y., Akimoto J., Omata, H., Moritake K., Hiranuma M., Hironaka C., Fujiwara Y., Beppu M. Concomitant treatment with temozolomide enhances apoptotic cell death in glioma cells induced by photodynamic therapy with talaporfin sodium. Photodiagnosis Photodyn. Ther., 11, 556-564, 2014. 4. Miki Y., Akimoto J., Hiranuma M., *Fujiwara Y. Effect of talaporfin sodium-mediated photodynamic therapy on cell death modalities in human glioblastoma T98G cells. J. Toxicol. Sci., 39(6), 821-827, 2014.（The Japanese Society of Toxicology, Pfizer Highly Cited Paper Award 2017） 5. Lee J.Y., Tokumoto M., Fujiwara Y., Lee M.Y., *Satoh M. Effects of cadmium on the gene expression of SLC39A1 coding for ZIP1 protein. Fundam. Toxicol. Sci., 1(4), 131-133, 2014. 6. Lee J.Y., Tokumoto M., Fujiwara Y., Lee M.Y., *Satoh M. The involvement of GPRC5B in cadmium toxicity in HK-2 cells. Fundam. Toxicol. Sci., 1(4), 165-167, 2014. 7. *Miki Y., Koyama K., Kurusu H., Hirano K., Beppu M., Fujiwara Y. Nucleolin is a receptor for maleylated-bovine serum albumin on macrophages. Biol. Pharm. Bull., 38(1), 116-121, 2015. |