Konno S, Tanaka M, Mizuguchi T, Toyokai H, Taguchi A, Taniguchi A, Hayashi Y. Peptide mixed phosphonates for covalent complex formation with thioesterases in nonribosomal peptide synthetases. J. Pept. Sci. 2023, e3532.
Mukaiyama M, Uchiyama C, Fukuda A, Nakazawa Y, Kuramochi Y, Shibata Y, Konno S, Muguruma K, Matsugaki N, Asari T, Ogawa K, Taguchi A, Takayama K, Taniguchi A, Nagumo Y, Senda T, Hayashi Y, Usui T. X-Ray Conformation and Structure-Activity Relationships of MA026, a Reversible Tight Junction Opener. J. Med. Chem. 2023, 66, 8717–8724.
Murakami H, Fujikawa Y, Mori M, Mosu N, Taguchi A, Hayashi Y, Inoue H, Kamisuki S. Development of a novel fluorogenic assay method for screening inhibitors of bovine leukemia virus protease and identification of mitorubrinic acid as an anti-BLV compound. Biosci. Biotechnol. Biochem. 2023, 87, 946–953.
Shida H, Taguchi A, Konno S, Takayama K, Taniguchi A, Hayashi Y. Establishment of One-Pot Disulfide-Driven Cyclic Peptide Synthesis with a 3-Nitro-2-pyridinesulfenate. Chem. Pharm. Bull. 2023, 71, 435–440.
Okamoto H, Murano SA, Ikekawa K, Katsuyama M, Konno S, Taguchi A, Takayama K, Taniguchi A, Hayashi Y. Inactivation of myostatin by photooxygenation using functionalized d-peptides. RSC Med. Chem. 2023, 14, 386–392.
Michiue K, Takayama K, Taniguchi A, Hayashi Y, Kogure K. Increasing Skeletal Muscle Mass in Mice by Non-Invasive Intramuscular Delivery of Myostatin Inhibitory Peptide by Iontophoresis. Pharmaceuticals 2023, 16, 397.
Hanada, K., Fukasawa, K., Hinata, H., Imai, S., Takayama, K., Hirai, H., Ohfusa, R., Hayashi, Y., Itoh, F. Combination therapy with anamorelin and a myostatin inhibitor is advantageous for cancer cachexia in a mouse model. Cancer Sci. 2022,113, 3547–3557.
Cui, Y.; Taguchi, A.; Shida, H.; Konno, S.; Takayama, K.; Taniguchi, A.; Hayashi, Y. Chemical synthesis of an HIV-1 protease analog with some amides in a polypeptide main chain replaced by disulfide bonds. Bull. Chem. Soc. Jpn. 2022, 95, 1156-1162.
Otani, Y.; Taguchi, A.; Hamada, K.; Hayashi, Y.; Yamaguchi, Y.; Baba, H. Influence of novel readthrough agents on myelin protein zero translation in the peripheral nervous system. Neuropharmacology 2022, 211, 109059.
Takayama, K.; Hitachi, K.; Okamoto, H.; Saitoh, M.; Odagiri, M.; Ohfusa, R.; Shimada, T.; Taguchi, A.; Taniguchi, A.; Tsuchida, K.; Hayashi, Y. Development of Myostatin Inhibitory d-Peptides to Enhance the Potency, Increasing Skeletal Muscle Mass in Mice. ACS Med. Chem. Lett. 2022, 13, 492–498.
Asari, T.; Ikeyama, H.; Taguchi, A.; Taniguchi, A.; Hayashi, Y.; Takayama, K. Proposal for the binding mode of the 23-mer inhibitory peptide to myostatin. Bioorg. Med. Chem. 2021, 40, 116181.
Hoshi, M.; Shiino, S.; Gomi, A.; Sakata, K.; Konno, S.; Hayashi, Y.; Kojima, M. In silico Design of Inhibitor Against SARS-CoV-2 Protease by Docking Simulation and ADMET Prediction. Bioimages 2021, 29, 11–21.
Konno, S.; Kobayashi, K.; Senda, M.; Funai, Y.; Seki, Y.; Tamai, T.; Schäkel, L.; Sakata, K.; Pillaiyar, T.; Taguchi, A.; Taniguchi, A.; Gütschow, M.; Müller, C. E.; Takeuchi, K.; Hirohama, M.; Kawaguchi, A.; Kojima, M.; Senda, T.; Shirasaka, Y.; Kamitani, W.; Hayashi, Y. 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV‐2 Agents. J. Med. Chem. 2021, 65, 2926-2939.
Kobayakawa, T.; Azuma, C.; Watanabe, Y.; Sawamura, S.; Taniguchi, A.; Hayashi, Y.; Tsuji, K.; Tamamura, H. Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application. J. Org. Chem. 2021, 86, 5091–5101.
Sasaki, K.; Muguruma, K,; Osawa, R.; Fukuda, A.; Taniguchi, A.; Hayashi, Y.; Kishimura, A.; Mori, T.; Katayama, Y. Synthesis and biological evaluation of a novel, monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy. RSC Med. Chem. 2021, 12, 406–409.
Kobayashi, K.; Taguchi, A.; Cui, Y.; Shida, H.; Muguruma, K.; Takayama, K.; Taniguchi, A.; Hayashi, Y. “On-resin” disulfide peptide synthesis with methyl 3-nitro-2-pyridinesulfenate. Eur. J. Org. Chem. 2021, 956–963.
Muguruma, K.; Osawa, R.; Fukuda, A.; Ishikawa, N.; Fujita, K.; Taguchi, A.; Takayama, K.; Taniguchi, A.; Ito, Y.; Hayashi, Y. Development of a high‐affinity antibody‐binding peptide for site‐specific modification. ChemMedChem 2021, 16, 1814–1821.
Uchiyama, C.; Fukuda, A.; Mukaiyama, M.; Nakazawa, Y.; Kuramochi, Y.; Muguruma, K.; Arimoto, M.; Ninomiya, A.; Kako, K.; Katsuyama, Y.; Konno, S.; Taguchi, A.; Takayama, K.; Taniguchi, A.; Nagumo, Y.; Usui, T.; Hayashi, Y. Structural revision of natural cyclic depsipeptide MA026 established by total synthesis and biosynthetic gene cluster analysis. Angew. Chem. Int. Ed. 2021, 60, 8792–8797.
Okamoto, H.; Taniguchi, A.; Usami, S.; Katsuyama, M.; Konno, S.; Taguchi, A.; Takayama, K.; Hayashi, Y. Development of functionalized peptides for efficient inhibition of myostatin by selective photooxygenation. Org. Biomol. Chem. 2021, 19, 199–207.
Akihiro Taguchi, Kiyotaka Kobayashi, Yan Cui, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi, Disulfide-driven cyclic peptide synthesis of human endothelin-2 with a solid-supported Npys-Cl, J. Org. Chem. (2020) 85, 1495-1503. doi: 10.1021/acs.joc.9b02362
Mariko Saitoh, Kentaro Takayama, Keisuke Hitachi, Akihiro Taguchi, Atsuhiko Taniguchi, Kunihiro Tsuchida, Yoshio Hayashi, Discovery of a follistatin-derived myostatin inhibitory peptide, Bioorg. Med. Chem. Lett., 2020, 30, 126892. doi: 10.1016/j.bmcl.2019.126892
1) Fumika Yakushiji, Hironari Tanaka, Kyohei Muguruma, Takahiro Iwahashi, Yuri Yamazaki, and Yoshio Hayashi, Water-Soluble Prodrug of Antimicrotubule Agent Plinabulin: Effective Strategy with Click Chemistry, Chem. Eur. J., 17, 12587–12590 (2011)
2) Kentarou Fukumoto, Kumi Adachi, Akihiro Kajiyama, Yuri Yamazaki, Fumika Yakushiji, Yoshio Hayashi, Development of a solid-supported biotinylation reagent for efficient biotin labeling of SH groups on small molecules, Tetrahedron Lett., 53, 535–538 (2012)
3) Yuri Yamazaki, Koji Tanaka, Benjamin Nicholson, Gordafaried Deyanat-Yazdi, Barbara Potts, Tomoko Yoshida, Akiko Oda, Takayoshi Kitagawa, Sumie Orikasa, Yoshiaki Kiso, Hiroyuki Yasui, Miki Akamatsu, Takumi Chinen, Takeo Usui, Yuki Shinozaki, Fumika Yakushiji, Brian R. Miller, Saskia Neuteboom, Michael Palladino, Kaneo Kanoh, George Kenneth Lloyd, and Yoshio Hayashi, Synthesis and Structure–Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure, J. Med. Chem., 55, 1056–1071 (2012)
4) Akihiro Taguchi, Shigenobu Nishiguchi, Masataka Shiozuka, Takao Nomoto, Mayuko Ina, Shouta Nojima, Ryoichi Matsuda, Yoshiaki Nonomura, Yoshiaki Kiso, Yuri Yamazaki, Fumika Yakushiji, and Yoshio Hayashi, Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy, ACS Med. Chem. Lett., 3, 118–122 (2012)
5) Henri-Obadja Kumada, Jeffrey-Tri Nguyen, Taeko Kakizawa, Koushi Hidaka, Tooru Kimura, Yoshio Hayashi and Yoshiaki Kiso, Development of [Ile40]HTLV-I protease inhibition assay using novel fluorogenic and chromogenic substrate, J.Pept.Sci., 17, 569–575 (2011)
1) 薬師寺文華
“温故知新:アミド結合形成の新展開 ”
有機合成化学協会誌, 69, 715-716 (2011)
2) 山崎 有理,林 良雄
環状ジペプチド型抗がん剤の創薬研究とケミカルバイオロジー展開
遺伝子医学MOOK 21号「最新ペプチド合成技術とその創薬研究への応用」、株式会社メディカル ドゥ、260-266 (2012)
1) Yuri Yamazaki, Makiko Sumikura, Koushi Hidaka, Hiroyuki Yasui, Yoshiaki Kiso, Fumika Yakushiji, and Yoshio Hayashi, Anti-microtubule ‘Plinabulin’ Chemical Probe KPU-244-B3 Labeled Both α-and β-Tubulin, Bioorg. Med. Chem., 18, 3169-3174(2010)
2) Noriko Shimizu, Shigeru Sugiyama, Mihoko Maruyama, Yoshinori Takahashi, Motoyasu Adachi, Taro Tamada, Koushi Hidaka, Yoshio Hayashi, Tooru Kimura, Yoshiaki Kiso, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Ryota Kuroki, Yusuke Mori, and Hiroyoshi Matsumura, Crystal Growth Procedure of HIV-1 Protease-inhibitor KNI-272 Complex for Neutron Structural Analysis at 1.9 A Resolution, Cryst. Growth Des., 10, 2990-2994(2010)
3) Yuri Yamazaki, Yui Kido, Koushi Hidaka, Hiroyuki Yasui, Yoshiaki Kiso, Fumika Yakushiji, and Yoshio Hayashi, Tubulin Photoaffinity Labeling Study with a Plinabulin Chemical Probe Possessing a Biotin Tag at the Oxazole, Bioorg. Med. Chem., 19, 595-602(2011)
1) 木曽 良明,林 良雄,相馬 洋平,日高 興士
生物分子システムを基盤とする統合創薬科学
MEDCHEM NEWS, 20, 2-8(2010)
1) Fumika Yakushiji, Jacques Maddaluno, Masahiro Yoshida, and Kozo Shishido, Diastereoselective Construction of Substituted Tetrahydropyrans Using an Intramolecular Oxy-Michael Strategy, Tetrahedron Lett., 50, 1504-1506 (2009)
2) Atsuhiko Taniguchi, Youhei Sohma, Yuta Hirayama, Hidehito Mukai, Tooru Kimura, Yoshio Hayashi, Katsumi Matsuzaki, Yoshiaki Kiso, “Click Peptide”: pH-triggered in Situ Production and Aggregation of Monomer Aβ1-42, ChemBioChem 10, 710-715 (2009)
3) Motoyasu Adachi, Takashi Ohhara, Kazuo Kurihara, Taro Tamada, Eijiro Honjo, Nobuo Okazaki, Shigeki Arai, Yoshinari Shoyama, Kaname Kimura, Hiroyoshi Matsumura, Shigeru Sugiyama, Hiroaki Adachi, Kazufumi Takano, Yusuke Mori, Koushi Hidaka, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kisoand Ryota Kuroki, Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High-resolution X-ray and Neutron Crystallography, Proc. Natl. Acad. Sci. USA, 106, 4641-4646 (2009)
4) Yuri Yamazaki, Yuki Mori, Akiko Oda, Yuka Okuno, Yoshiaki Kiso, and Yoshio Hayashi, Acid Catalyzed Monodehydro-2,5-diketopiperazine Formation from N-α-ketoacyl Amino Acid Amides, Tetrahedron, 65, 3688-3694 (2009)
5) Thomas Regnier, Diganta Sarma, Koushi Hidaka, Usman Bacha, Ernesto Freire, Yoshio Hayashi, and Yoshiaki Kiso, New Developments for the Design, Synthesis and Biological Evaluation of Potent SARS-CoV 3CLproInhibitors, Bioorg. Med. Chem. Lett., 19, 2722-2727 (2009)
6) Koushi Hidaka, Tooru Kimura, Hamdy M. Abdel-Rahman, Jeffrey-Tri Nguyen, Keith F. McDaniel, William E. Kohlbrenner, Akhteruzzaman Molla, Motoyasu Adachi, Taro Tamada, Ryota Kuroki, Noriko Katsuki, Yoshiaki Tanaka, Hikaru Matsumoto, Jun Wang, Yoshio Hayashi, Dale J. Kempfand Yoshiaki Kiso, Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S2’ Pocket, J. Med. Chem., 52, 7604–7617 (2009)
7) Shigenobu Nishiguchi, Magne O. Sydnes, Akihiro Taguchi, Thomas Regnier, Tetsuya Kajimoto, Manabu Node, Yuri Yamazaki, Fumika Yakushiji, Yoshiaki Kiso, and Yoshio Hayashi, Total Synthesis of (+)-Negamycin and Its 5-epi-derivative, Tetrahedron, 66, 314-320 (2010)
1) Truncation and Non-natural Amino Acid Substitution Studies on HTLV-I Protease Hexapeptidic Inhibitors, Bioorg. Med. Chem. Lett., 18, 366-370 (2008)
Jeffrey-Tri Nguyen*1, Meihui Zhang*1,2, Henri-Obadja Kumada*1, Ayako Itami*1, Keiji Nishiyama*1, Tooru Kimura*1, Maosheng Cheng*2, Yoshio Hayashi, Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University, *2 Shenyang Pharmaceutical University
2) Fmoc-based Solid Phase Chemical Synthesis of 71-meric Neuregulin 1-beta1, an Epidermal Growth Factor-like Domain, J. Peptide Sci., 14, 261-266 (2008)
Taeko Kakizawa*, Shizuyo Koide-Yoshida*, Tooru Kimura*, Hiromasa Uchimura*, Yoshio Hayashi, Kazuki Saito*, Yoshiaki Kiso*
* Kyoto Pharmaceutical University
3) BACE1 Inhibitors: Optimization by Replacing the P1′ Residue with Non-acidic Moiety, Bioorg. Med. Chem. Lett., 18, 1649-1653, (2008)
Yoshio Hamada*1, Hamdy Abdel-Rahman*1, Abdellah Yamani*1, Jeffrey-Tri Nguyen*1, Monika Stochaj*1, Koushi Hidaka*1, Tooru Kimura*1, Yoshio Hayashi, Kazuki Saito*1, Shoichi Ishiura*2 and Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University, *2 University of Tokyo
4) Novel Non-peptidic and Small-sized BACE1 Inhibitors, Bioorg. Med. Chem. Lett., 18, 1654-1658, (2008)
Yoshio Hamada*1, Hiroko Ohta*1, Naoko Miyamoto*1, Ryoji Yamaguchi*1, Abdellah Yamani*1, Koushi Hidaka*1, Tooru Kimura*1, Kazuki Saito*1, Yoshio Hayashi, Shoichi Ishiura*2 and Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University, *2 University of Tokyo
5) Combination of Non-natural D-Amino Acid Derivatives and Allophenylnorstatine-Dimethylthioproline Scaffold in HIV Protease Inhibitors Have High Efficacy in Mutant HIV, J. Med. Chem., 51, 2992-3004, (2008)
Shingo Nakatani*1, Koushi Hidaka*1, Ei’ichi Ami*1, Koichiro Nakahara*1, Akihiko Sato*2, Jeffrey-Tri Nguyen*1, Yoshio Hamada*1, Yasuko Hori*1, Nobuyuki Ohnishi*1, Akinori Nagai*1, Tooru Kimura*1, Yoshio Hayashi and Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University *2 Shionogi Co. Ltd
6) Efficient Total Synthesis of (+)-Negamycin, a Potential Chemotherapeutic Agent for Genetic Diseases, Chem. Comm., 2379-2381, (2008)
Yoshio Hayashi, Thomas Regnier*1, Shigenobu Nishiguchi*1, Magne O. Sydnes*1, Daisuke Hashimoto*1, Junya Hasegawa*1, Takahiro Katoh*1, Tetsuya Kajimoto*1, Masataka Shiozuka*2, Ryoichi Matsuda*2, Manabu Node*1 and Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University, *2 University of Tokyo
7) Development of Novel Water-soluble Photocleavable Protective Group and Its Application for Design of Photoresponsive Paclitaxel Prodrugs, Bioorg. Med. Chem., 16, 5389-5397, (2008)
Mayo Noguchi*1, Mariusz Skwarczynski*1, Halan Prakash*2, Shun Hirota*2, Tooru Kimura*1, Yoshio Hayashi and Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University, *2 Nara Institute of Science and Technology
8) Synthesis and Activity of Tetrapeptidic HTLV-I Protease Inhibitors Possessing Different P3-cap Moieties, Bioorg. Med. Chem., 16, 5795-5802, (2008)
J Meihui Zhang*1,2, Jeffrey-Tri Nguyen*1, Henri-Obadja Kumada*1, Tooru Kimura*1, Maosheng Cheng*2, Yoshio Hayashi and Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University, *2 Shenyang Pharmaceutical University
9) Design, Synthesis and Biophysical Properties of a Helical A 1-42 Analog: Inhibition of Fibrillogenesis and Cytotoxicity, Biochem. Biophys. Res. Commun., 371, 777-780, (2008)
Katsumi Matsuzaki*1, Takuma Okada*1, Miho Tsukuda*1, Keisuke Ikeda*1, Youhei Sohma*2, Yousuke Chiyomori*2, Atsuhiko Taniguchi*2, Setsuko Nakamura*2, Nui Ito*2, Yoshio Hayashi and Yoshiaki Kiso*2
*1 Kyoto University, *2 Kyoto Pharmaceutical University
10) Locking the Two Ends of Tetrapeptidic HTLV-I Protease Inhibitors Inside the Enzyme, Bioorg. Med. Chem., 16, 6880-6890, (2008)
Meihui Zhang*1,2, Jeffrey-Tri Nguyen*1, Henri-Obadja Kumada*1, Tooru Kimura*1, Maosheng Cheng*2, Yoshio Hayashi and Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University, *2 Shenyang Pharmaceutical University
11) Metabolism of Phenylahistin Enantiomers by Cytochromes P450: a Possible Explanation for their Different Cytotoxicity, Drug Metabolism and Disposition, 36, 2381-2392, (2008)
Lionel Perrin*1, Caroline Aninat*2, Veronique Hamon*1, Yoshio Hayashi, Catherine Abadie*3, Bruno Heyd*4, Francois Andre*1, Marcel Delaforge*1
*1 CEA-CNRS-URA 2096, *2Université de Rennes I, *3 Kaly Cell Besançon, *4 C. H. U. de Besançon Hôpital Jean Minjoz
12) Crystallization and Preliminary Neutron Diffraction Studies of HIV-1 Protease Cocrystallized with Inhibitor KNI-272, Acta Cryst. F, 64, 1003-1006, (2008)
Hiroyoshi Matsumura*1,2,3, Motoyasu Adachi*4, Shigeru Sugiyama*1,3, Shino Okada*3, Megumi Yamakami*3, Taro Tamada*4, Koushi Hidaka*5, Yoshio Hayashi, Tooru Kimura*5, Yoshiaki Kiso*5, Tomoya Kitatani*1,3, Sho Maki*1,3, Hiroshi Y. Yoshikawa*1,3, Hiroaki Adachi*1,2,3, Kazufumi Takano*1,2,3, Satoshi Murakami*2,3,6, Tsuyoshi Inoue*1,2,3, Ryota Kuroki*4 and Yusuke Mori*1,2,3
*1 Osaka University, *2 SOSHO Inc., *3 CREST JST, *4 Kyoto Pharmaceutical University, *5 Tokyo Institute of Technology
13) Oligoarginine-based Prodrugs with Self-cleavable Spacers for Caco-2 Cell Permeation, Chem. Pharm. Bull., 56, 1515-1520, (2008)
Kentaro Takayama*1, Yuka Suehisa*2, Takuya Fujita*2, Jeffrey-Tri Nguyen*2, Shiroh Futaki*1, Akira Yamamoto*2, Yoshiaki Kiso*2 and Yoshio Hayashi
*1 Kyoto University, *2 Kyoto Pharmaceutical University
14) D Antimalarial Activity Enhancement in Hydroxymethylcarbonyl (HMC) Isostere-based Dipeptidomimetics Targeting Malarial Aspartic Protease Plasmepsin, Bioorg. Med. Chem., 16, 10049-10060, (2008)
Koushi Hidaka*1, Tooru Kimura*1, Adam J.Ruben*2, Tsuyoshi Uemura*1, Mami Kamiya*1, Aiko Kiso*1, Tetsuya Okamoto*1, Yumi Tsuchiya*1, Yoshio Hayashi, Ernesto Freire*2 and Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University, *2 John Hopkins University
15) Controlled Production of Amyloid peptide from a Phototriggered, Water-soluble Precursor Click Peptide, ChemBioChem, 9, 3055-3065, (2008)
Atsuhiko Taniguchi*1, Mariusz Skwarczynski*1, Youhei Sohma*1, Takuma Okada*2, Keisuke Ikeda*2, Halan Prakash*3, Hidehito Mukai*1, Yoshio Hayashi, Tooru Kimura*1, Shun Hirota*3, Katsumi Matsuzaki*2 and Yoshiaki Kiso*1
*1 Kyoto Pharmaceutical University, *2 Kyoto University, *3 Nara Institute of Science and Technology
16) Tubulin Photoaffinity Labeling with Biotin-tagged Derivatives of Potent Diketopiperazine Antimicrotubule Agents, ChemBioChem, 9, 3074-3081, (2008)
Yuri Yamazaki, Kyoko Kohno*1, Hiroyuki Yasui*1, Yoshiaki Kiso*1, Miki Akamatsu*2, Benjamin Nicholson*3, Gordafaried Deyanat-Yazdi*3, Saskia Neuteboom*3, Barbara Potts*3, G. Kenneth Lloyd*3 and Yoshio Hayashi
*1 Kyoto Pharmaceutical University, *2 Kyoto University, *3 Nereus Pharmaceuticals Inc.
1) Youhei Sohma, Taku Yoshiya, Atsuhiko Taniguchi, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso, Development of O-acyl isopeptide method, Biopolymers Peptide Science, 88, 253-262 (2007)
2) Koushi Hidaka, Tooru Kimura, Yumi Tsuchiya, Mami Kamiya, Adam J. Ruben, Ernesto Freire, Yoshio Hayashi, and Yoshiaki Kiso, Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II, Bioorg. Med. Chem. Lett., 17, 3048-3052 (2007)
3) Taku Yoshiya, Atsuhiko Taniguchi, Youhei Sohma, Fukue Fukao, Setsuko Nakamura, Naoko Abe, Nui Ito, Mariusz Skwarczynski, Tooru Kimura, Yoshio Hayashi, and Yoshiaki Kiso, “O-Acyl isopeptide method” for peptide synthesis: synthesis of forty kinds of “O-acyl isodipeptide unit” Boc-Ser/Thr(Fmoc-Xaa)-OH, Org. Biomol. Chem. 5, 1720-1730 (2007)
4) Tooru Kimura, Jeffrey-Tri Nguyen, Hikoichiro Maegawa, Keiji Nishiyama, Yasuhiro Arii, Yasuko Matsui, Yoshio Hayashi, and Yoshiaki Kiso, Chipping at large, potent human T-cell leukemia virus type 1 protease inhibitors to uncover smaller, equipotent inhibitors, Bioorg. Med. Chem. Lett., 17, 3276-3280 (2007)
5) Ei’ichi Ami, Koichiro Nakahara, Akihiko Sato, Jeffrey-Tri Nguyen, Koushi Hidaka, Yoshio Hamada, Shingo Nakatani, Tooru Kimura, Yoshio Hayashi, and Yoshiaki Kiso, Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties, Bioorg. Med. Chem. Lett., 17, 4213-4217 (2007)
6) Yoshio Hayashi, Kentaro Takayama, Yuka Suehisa, Takuya Fujita, Jeffrey-Tri Nguyen, Shiroh Futaki, Akira Yamamoto, and Yoshiaki Kiso, Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption, Bioorg. Med. Chem. Lett., 17, 5129-5132 (2007)
7) Atsuhiko Taniguchi, Taku Yoshiya, Naoko Abe, Fukue Fukao, Youhei Sohma, Tooru Kimura, Yoshio Hayashi, and Yoshiaki Kiso, ‘O-Acyl isopeptide method’ for peptide synthesis: Solvent effects in the synthesis of Aß 1-42 isopeptide using ‘O-acyl isodipeptide unit’, J. Peptide Sci., 13, 868-874 (2007)
8) Hideki Abe, Kei-ichi Takaya, Kazuhiro Watanabe, Sakae Aoyagi, Chihiro Kibayashi, and Tadashi Katoh, Spirocyclization of an N-Acyliminium Ion with Substituted Pyridine: Synthesis of Tricyclic Spirolactams Possessing Pyridine or Pyridone Nucleus, Heterocycles, 74, 205-210 (2007)
9) Naoki Yamazaki, Takeshi Suzuki, Yuta Yoshimura, Chihiro Kibayashi, and Sakae Aoyagi, Asymmetric Synthesis of Stellettamides A and C, Heterocycles, 75, 285-290 (2008)